Question

In the module, you learned about an experiment in which researcher optogenetically stimulated neurons in the VTA and examined behavioral and neural responses. See data below. А B 600 Pre-Test Post-Tost 1.0 600 1.0 500 500 0.8 0.8 400 400 0.6 0.6 300 0.4 300 S 200 04 200 100 0.2 100 02 0 0 0 No Stim Pre Post Pre Post Phasic Center Chamber Chamber Chamber Tonic Center No Stim Chamber Chamber Chamber D Phasic Stimulation Tonic Stimulation 3 A 24V 13V 44V 13V wusz 2 MA Based on this data, how do phasic and tonic activation of the ventral tegmental area impact dopamine release in the nucleus accumbens? Neither type of stimulation activates significant DA release in this region Phasic stimulation activates significant DA release, but not tonic Tonic stimulation activates significant DA release, but not tonic Both types of stimulation activate significant DA release in this region

Answer 1

The correct answer is option B - Phasic stimulation activates significant DA release, but not Tonic.

Explanation: The Dopamine receptors normally release dopamine at slow rates but spontaneously which is called Tonic but sometimes they fire excess amounts of dopamine which is called burst or phasic firing.