Question

Glycolysis is the first part of glucose' catabolic journey to complete oxidation. It is not until pyruvate, the end product of glycolysis, is oxidized by the pyruvate dehydrogenase complex, that the first glucose carbons are oxidized to CO2. The overall PDH reaction is shown below. Identify the glucose carbon atoms that are removed in this reaction and the glucose atoms that are destined to become part of acetyl CoA. 0 0 C3, C4 →Ć Pyruvate dehydrogenase + NAD+ + COASH complex + + NADH + H+ C5 → Ć=o - COA C1, C6 → CH3 Acetyl COA Pyruvate glucose carbons removed from pyruvate glucose carbons in the carboxyl group of acetate glucose carbons in the methyl group of acetate glucose carbons C1, C6 glucose carbons C2, C5 glucose carbons C3, C4

Answer 1

Pyruvate dehydrogenase catalyzes the transition reaction in aerobic respiration.
It mediates the oxidative decarboxylation of Pyruvate to produce Acetyl CoA.

Glucose carbons removed from Pyruvate = C3 and C4
Glucose carbons in the carboxyl group of acetate = C2 and C5
Glucose carbons in the methyl group of acetate = C1 and C6

See the image

о, он Hico н-с-ОН НО-С-н н-с-ОН H-C-OH °CН,ОН 3, 4С 2. 5 2,5c=0 H3C so 1,6CH3 D-Glucose Pyruvate Acetyl COA

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