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3.a) from a primary literature article, describe Peto’s Paradox. Explain what is it and its relationship...

3.a) from a primary literature article, describe Peto’s Paradox. Explain what is it and its relationship with cancer?

b) explain why the LIF gene is also called Zombie?
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3 a) Peto's paradox is the observation, named after Richard Peto, that at the species level, the incidence of cancer does not appear to correlate with the number of cells in an organism. For example, the incidence of cancer in humans is much higher than the incidence of cancer in whales

This is despite the fact that a whale has many more cells than a human. If the probability of carcinogenesis were constant across cells, one would expect whales to have a higher incidence of cancer than humans.

b) LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.LIF gene is also known as zombie since ,its resurrection has allowed it to function as something of a killer of living cells.

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