Question

Please give short and concise explanations as to what the figure provided actually means , why they are important to the research they have conducted, and what the pathways corresponds to/represent. Will rate / need ASAP ***Please support all information provided.

This figure belongs to an article based on cancer research , I have provided the intro.

RESEARCH ARTICLE Resistant state Sensitive state JAK21 PI3K pathway STAT STAT STATMAPK pathway MAPK pathway AKT ERK STAT ST BAD Liberation of BCL-X BCL-X Pim1 Inhibition of mitochondrial apoptosis Fig. 6. A BADIBCL-X-centric model goveming survival in JAK inhibitor-resistant and cells. In the sensitive state (gray dashed line), suvival is predominantly controlled by canonical JAK signaling-mediated inactivation of BAD at the Ser1 site. In the resistant state (black dashed line), RAS effector pathways ERK and AKT, driven by activating mutations in RAS or other upstream signals, provide compensatory survival signals at the functionally equivalent Ser2 and Ser30 sites, rescuing the efflects of JAK2 irhibition and representing a coalescent signaling node through which survival is orchestrated in JAK2wBIm cells.

Answer 1

FIG 6.

In the normal or sensitive cells to the JAK inhibition, the survival is determined by the inactivation of BAD protein at the serine site. In the resistant state, formed by the RAS mutations, the signaling pathway provides the alternative mechanisms for survival.