Are proteins for secretion translated while they are being transferred across the ER membrane?
Are proteins for secretion translated while they are being transferred across the ER membrane?
Homework Answers
Secretory proteins were targeted to the Endoplasmic retiuculum by the signal sequence at amino terminus,was removed duringand incorporated to the growing polypeptide chain in the ER. This wasshowed by experiments that translation of secretory protein mRNAs on free ribosomes yielded proteins that retained their signal sequences and larger than normal secreted proteins. , when microsomes added to the system, the growing polypeptide chain are incorporated into the microsomes and the signal sequences are removed by the proteolytic cleavage.
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Are proteins for secretion translated while they are being
transferred across the ER membrane?
1. (1.5 pts) Entering the ER: Translocation of proteins across the membrane of the ER is usually ...
Please answer letter B!
1. (1.5 pts) Entering the ER: Translocation of proteins across the membrane of the ER is usually studied using microsomes (vesicles made from rough endoplasmic reticulum. Microsomes of the rough ER carry ribosomes attached to their outer surface. Translocation of proteins across the microsomal membrane can be assessed by several experimental criteria: (1) the newly synthesized protein is protected from added proteases, but not when detergents are present to solubilize the protecting lipid bilayer; (2) the...
QUESTION 2 Proteins are translocated into the ER lumen by being pushed by translation through the...
QUESTION 2 Proteins are translocated into the ER lumen by being pushed by translation through the lipid bilayer of the ER membrane. through an aqueous channel created by the Sec61 protein. by being pulled by BiP across the lipid bilayer of the ER membrane. by flippases.
Select all of proteins below that are made on the membrane-bound ribosomes of the rough ER?...
Select all of proteins below that are made on the membrane-bound ribosomes of the rough ER? A. ER chaperones B. Mitochondrial proteins C. Secreted Proteins D. Receptors on the plasma membrane E. Nuclear proteins F. Golgi proteins G. Cytosolic proteins
#3 2. Explain the synthesis of lipids at the ER membrane and how transmembrane proteins are...
#3
2. Explain the synthesis of lipids at the ER membrane and how transmembrane proteins are inserted. 3. Compare and contrast types of membrane transport including transport proteins.
Explain the transport of extracellular membrane proteins following their post translational modification in the ER.
Explain the transport of extracellular membrane proteins following their post translational modification in the ER.
What is Co-translational insertion of secreted and transmembrane proteins into the ER membrane including translocon, secreted...
What is Co-translational insertion of secreted and transmembrane proteins into the ER membrane including translocon, secreted proteins, type 1 transmembrane protein, type 2 transmembrane proteins?
1.Draw the pathway to import and export proteins across the nuclear membrane. Include all parts and...
1.Draw the pathway to import and export proteins across the nuclear membrane. Include all parts and players relevant to the process. 2.Draw the process involved in the import of proteins into the matrix of the mitochondria.
Determine whether the following classes of proteins are synthesized on free ribosomes or ER docked ribosomes....
Determine whether the following classes of proteins are synthesized on free ribosomes or ER docked ribosomes. a) Single-pass membrane proteins b) Multi-pass membrane proteins c) Peripheral membrane proteins (on the cytosolic side) d) Peripheral membrane proteins (on the luminal side) e) Peripheral membrane proteins (on the extracellular side) f) Fatty acid-anchored membrane proteins g) GPI- anchored membrane proteins - Where would a protein likely go if you were to remove a characteristic hydrophobic membrane spanning domain?
A membrane is being engineered for filtering proteins. Its pores have charged surfaces, so some of...
A membrane is being engineered for filtering proteins. Its pores have charged surfaces, so some of the sieving effect of the membrane comes from the electrostatic repulsion of the proteins from the walls of the pore. Consider the membrane pore to be a parallel slit 10 nm in width and the surface potential to be 50 mV. Assume the potential at the midplane to be low, and calculate it for the case of 15 mM ionic strength (coming from a...
The potential difference across the cell membrane is due to the unequal distribution of ________ across...
The potential difference across the cell membrane is due to the unequal distribution of ________ across the membrane. phospholipids and proteins acids and bases carbohydrate molecules water molecules cations and anions
Please answer letter B!
1. (1.5 pts) Entering the ER: Translocation of proteins across the membrane of the ER is usually studied using microsomes (vesicles made from rough endoplasmic reticulum. Microsomes of the rough ER carry ribosomes attached to their outer surface. Translocation of proteins across the microsomal membrane can be assessed by several experimental criteria: (1) the newly synthesized protein is protected from added proteases, but not when detergents are present to solubilize the protecting lipid bilayer; (2) the...
QUESTION 2 Proteins are translocated into the ER lumen by being pushed by translation through the lipid bilayer of the ER membrane. through an aqueous channel created by the Sec61 protein. by being pulled by BiP across the lipid bilayer of the ER membrane. by flippases.
#3
2. Explain the synthesis of lipids at the ER membrane and how transmembrane proteins are inserted. 3. Compare and contrast types of membrane transport including transport proteins.
A membrane is being engineered for filtering proteins. Its pores have charged surfaces, so some of the sieving effect of the membrane comes from the electrostatic repulsion of the proteins from the walls of the pore. Consider the membrane pore to be a parallel slit 10 nm in width and the surface potential to be 50 mV. Assume the potential at the midplane to be low, and calculate it for the case of 15 mM ionic strength (coming from a...
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