Question

If your student ID number (show)ends in an even number solve 26.2 26.2. Describe in your own words how 2 carbons from pyruvate enter the TCA Cycle (the reactions and intermediates associated with pyruvate dehydrogenase) (25 points)

Answer 1

TCA cycle of krebs Cycle is the final common Oxidahue pathway that oxidises Acety.CoA to Co₂ Paruvate, the end product of glycolysis is oxidately decarboxylated to Acetyl Co.A by pyruvate dehydrogenase. This steps links glycolysis Acetyl CoA enters into the to TCA cycle. and then Krebs cycle. CONVERSION OF PYRUVATE TO DOKTYL COA by PD D4 Pyruvate Dedydrogenase) The overall deahon can be represented as: coo COASH NART TPP NADH THT Repoeimide - - FAD > Pyruvate dehydrogenase complex c=0 cao + CO2 CH3 CH₃ Pyruvate Acetyl-CoA complex which and other 8 PDH complex is a multienzyme consists of 3 enzymes, 5 coenzymes proteens.

Enzymes and coenzymes of the POH complex : Abbreviation Coenzyme E) Enzyme Pyruvate olehydrogenase Dihydrolipoyl transacetylase Dihydrolipoyl dehydrogenase TPP COASH, Lipoamdo FAD NAD+ E3 Among the coenzymes, TPPL Thymine pyrophosphate) is often used Ro decarboxylaton reachons.depole and helps is acetyl transfer and oxidation reactions. Coenzyme A has a free theol group that can form thwesters which are energy-rich compounds FA and NAD+ act as oxidising agent I electron aleptors. Thus, the 3-c compound Pyruvate is now converted into Acelys Co.A to enter into Krebs cycle.