Question

10.	Alternative splicing is NOT responsible for which of the following developmental occurrences?
	generation of K+ ion channels in ear hair cells that open at different Ca2+ concentrations and tune hearing generation of neuronal synaptic connections in Drosophila differential expression of beta, gamma, delta, and epsilon globin genes throughout development sex differentiation in Drosophila
11.	In birds, a gene encoding a Ca2+-activated K+ channel is expressed in auditory hair cells as multiple mRNAs, which encode for proteins that open at different Ca2+ concentrations. The Ca2+ concentration at which the channel opens allows these cells to respond to different sound frequencies. Which one of the following would explain the appearance of the various isoforms of this particular channel?
	alternative splicing the presence of chain-terminating mutations the absence of compensating mutations exon skipping

Answer 1

Answer

Que 10 correct answer is option 3rd i e. differential expression of beta, gamma, delta, and epsilon globin genes throughout development.

Beacuse expression of beta gamma delta epsilon globin genes is not function of laternative splicing.

It is part of hemoglobin structure switxhing at embryonic fatal and adult stage.

HBZ -- HBA2 HBA1 Chr. 16 = Gower 1/11 HDF HbA Birth Stage: Embryonic Site: Yolk Sac Fetal Fetal Liver Adult Bone Marrow Age (weeks) 6 12 18 24 30 36 Post-Conception 6 12 18 24 30 36 42 48 Post-Natal Chr. 11 -12396@M HH8B) LCR HBE HBG2 HBG1 HBD HBB

Que 11 correct answer is option first alternative splicing.because K channel alpha-subunit derives its molecular diversity by alternative splicing of a single-gene transcript to yield multiple isoforms that differ in their sensitivity to intracellular Ca2+ and voltage, cell surface expression and post- translational modification.