![Background Problem N° 4 Objective: To use pedigrees in a case of an inherited disease in humans in order to determine the type of generic inheritance 3 4 According to the National Cancer Institute (NCI), a pedigree is an illustration of family history and it shows relationships between family members and patterns of inheritance for certain traits and diseases.3 3 2 3 Pedigrees use standard symbols and conventions: O female: male; affected | Analyze the pedigree for myopia (nearsightedness) in a human family, depicted above female: affected male: proband, (a.k.a consultand, the subject of genetic studies Check the handout Standard Pedigree Nomenclature in folder Minicourse 1 for more symbols). Leftmost Roman numerals generation considered in the pedigree; Arabic numerals per row: individuals in that particular generation, regardless of what nuclear family they are in; combinations of Roman and Arabic numerals, a certain individual in a particular generation; e.g., affected female llI-2, unaffected male I-3] Question: What type of genetic inheritance is observed in this family for myopia? Here are a few pointers: Is there a hemizvgous allele, linked to the Y chromosome? Is it a hemizygous allele linked to the X chromosome? Is it a recessive or dominant autosomal trait? Yes No Yes No Recessive Dominant Assuming that myopia is determined by a single allele, use the symbols M, m and assign genotypes to all individuals on the pedigree above Which individuals genotypes would help in distinguishing what kind of inheritance for this trait is in play here and why? Remember that individuals are designated with the generation (Roman numeral) and the individual number (Arabic numeral), for example, 14, 112, Il13, etc. Homozygous: two identical alleles in both homologous chromosomes, AA, or ga Answer and explanation Heterozygous: different alleles on the homologous chromosomes, Ag Hemizvgous: one allele is present in one chromosome but not in the other. This can happen in sex-chromosomes, XYSDR XHY](http://img.homeworklib.com/questions/a1980f60-08f3-11ec-959d-7ba1c9a0621e.png?x-oss-process=image/resize,w_560)
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Background Problem N° 4 Objective: To use pedigrees in a case of an inherited disease in...
A family tree of sorts is called a pedigree. The symbols used for a pedigree are:...
A family tree of sorts is called a pedigree. The symbols used for a pedigree are: O female, unaffected Siblings are placed in birth order from left to right and are labeled with Arabic numerals. Each generation is labeled with a Roman numeral. Therefore the male exhbiting the female, affected male, unaffected trait in the pedigree below in the bottom, center would be identified as Il-4. male, affected -utington's Disease REVIEW – Reading a pedigree and dominant/recessive Inheritance. For questions...
Part B Determining genotypes in pedigrees of X-linked conditions The pedigree from Part A is shown...
Part B Determining genotypes in pedigrees of X-linked
conditions
The pedigree from Part A is shown below. Fill in the most likely
genotypes of the indicated individuals in the pedigree. Note that a
dominant allele followed by an underscore (_) indicates that either
the dominant or the recessive allele may be present at the second
position. Drag one pink label (for condition A, autosomal
recessive) to each pink target. Drag one blue label (for condition
B, X-linked recessive) to each...
PEDIGREES When a trait follows Mendelian inheritance it is often possible to figure out its dominance...
PEDIGREES When a trait follows Mendelian inheritance it is often possible to figure out its dominance state by using a pedigree. Below are four pedigrees for four different traits. They are all autosomal traits (meaning they are not inherited on the X or Y chromosomes). For each trait, determine if it is dominant, recessive or unable to be determined. And explain each answer If it helps your explanation, you may label the symbols with letters Remember squares are males, circles...
모모모 < 모 2 1 | 미모 모 오 or lo III = - - genetic...
모모모 < 모 2 1 | 미모 모 오 or lo III = - - genetic disorder is segregating. 3. Each of the pedigrees shown represents a human family within which a genetic disorder is se Assume the two traits are extremely rare in the population and completely penetrant. Part 1. For the first pedigree. lisorder: autosomal recessive, autosomal a. Determine the most probable inheritance pattern of the disorder: autosomal recessive dominant, X-linked recessive or X-linked dominant. b. Indicate the...
Web Genotypes and phenotypes for some common single gene inheritance patterns. Inheritance Pattern Genotype Phenotype Affected...
Web Genotypes and phenotypes for some common single gene inheritance patterns. Inheritance Pattern Genotype Phenotype Affected Affected Not affected AA Autosomal Dominant Aa aa NN Not affected Not affected Affected Autosomal Recessive Nn nn XXN XNX Normal female Normal female Affected female Normal male Affected male Sex-linked Recessive X"X xNY X"Y Pedigree Analys is Instructions: 1. Examine the following three pedigrees. 2. Determine the most probable pattern of inheritance for each pedigree and record it in the space provided at...
Challenge Question! (Combines Law of Independent Assortment and Sex-Linkage) ratio in their Fi offspring generation? Invent...
Challenge Question! (Combines Law of Independent Assortment and Sex-Linkage) ratio in their Fi offspring generation? Invent and design your recessive allele, and pink coat is caused by an autosomal dominant allele (wild type roma pure line is crossed with a pink male from a pure line, what will be the phenotypic Autosomal dominant disorders are associated with genes found on autosome chromosomes that have a "spoiler" effect for the phenotype. In other words, if you inherit one spoiler dominant allele...
Genetics Pedigree Worksheet 1. Use the below pedigree chart to answer the following questions about dimples....
Genetics Pedigree Worksheet 1. Use the below pedigree chart to answer the following questions about dimples. The Dimple gene controls whether a person has dimples or doesn't have dimples. Dimples is dominant to no dimples. Place the genotypes of each individual below its symbol. O Dimples gene (D) Dimples is dominant to no dimples 12 13 14 A) How many family members have Dimples? B) What is the genotype of individual 3 and 4? C) Can cither individual #8 or...
. O . Using Pedigrees to hypothesize patterns of inheritance 5. For each of the pedigree...
. O . Using Pedigrees to hypothesize patterns of inheritance 5. For each of the pedigree charts on the following page, determine which pattern of inheritance most likely explains the observed pattern of traits in the family shown. Observe the general patterns in the pedigree charts on the following page o males vs females? parents with disease? Compare these patterns with the clues on the previous page to hypothesize a pattern of inheritance Based on this pattern of inheritance, use...
Look carefully at the pedigrees below and: 1) indicate whether the transmission appears autosomal or sex-linked...
Look carefully at the pedigrees below and:
1) indicate whether the transmission appears autosomal or
sex-linked
2) indicate whether the transmission appears dominant or
recessive
3) provide at least two characteristics for each that support
your conclusion.
In general, the following characteristics suggest (but do not prove) specific inheritance patterns: Autosomal recessive inheritance: -affected individuals can be born to unaffected parents -if both parents are affected, all children are affected -observable effect of relatedness (consanguinity) -horizontal" inheritance: trait appears at...
Question 3 The following human pedigree shows a family affected by a specific disease. Assume that...
Question 3 The following human pedigree shows a family affected by a specific disease. Assume that the individuals marked with an asterisk () do not carry any allele associated with the affected phenotype and that no other mutation spontaneously occurs. Also assume complete penetrance a) State the most likely mode of inheritance for this disease. Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive b) Write all possible genotypes of the following individuals in the pedigree. Use the uppercase...
A family tree of sorts is called a pedigree. The symbols used for a pedigree are: O female, unaffected Siblings are placed in birth order from left to right and are labeled with Arabic numerals. Each generation is labeled with a Roman numeral. Therefore the male exhbiting the female, affected male, unaffected trait in the pedigree below in the bottom, center would be identified as Il-4. male, affected -utington's Disease REVIEW – Reading a pedigree and dominant/recessive Inheritance. For questions...
Part B Determining genotypes in pedigrees of X-linked
conditions
The pedigree from Part A is shown below. Fill in the most likely
genotypes of the indicated individuals in the pedigree. Note that a
dominant allele followed by an underscore (_) indicates that either
the dominant or the recessive allele may be present at the second
position. Drag one pink label (for condition A, autosomal
recessive) to each pink target. Drag one blue label (for condition
B, X-linked recessive) to each...
PEDIGREES When a trait follows Mendelian inheritance it is often possible to figure out its dominance state by using a pedigree. Below are four pedigrees for four different traits. They are all autosomal traits (meaning they are not inherited on the X or Y chromosomes). For each trait, determine if it is dominant, recessive or unable to be determined. And explain each answer If it helps your explanation, you may label the symbols with letters Remember squares are males, circles...
모모모 < 모 2 1 | 미모 모 오 or lo III = - - genetic disorder is segregating. 3. Each of the pedigrees shown represents a human family within which a genetic disorder is se Assume the two traits are extremely rare in the population and completely penetrant. Part 1. For the first pedigree. lisorder: autosomal recessive, autosomal a. Determine the most probable inheritance pattern of the disorder: autosomal recessive dominant, X-linked recessive or X-linked dominant. b. Indicate the...
Web Genotypes and phenotypes for some common single gene inheritance patterns. Inheritance Pattern Genotype Phenotype Affected Affected Not affected AA Autosomal Dominant Aa aa NN Not affected Not affected Affected Autosomal Recessive Nn nn XXN XNX Normal female Normal female Affected female Normal male Affected male Sex-linked Recessive X"X xNY X"Y Pedigree Analys is Instructions: 1. Examine the following three pedigrees. 2. Determine the most probable pattern of inheritance for each pedigree and record it in the space provided at...
Challenge Question! (Combines Law of Independent Assortment and Sex-Linkage) ratio in their Fi offspring generation? Invent and design your recessive allele, and pink coat is caused by an autosomal dominant allele (wild type roma pure line is crossed with a pink male from a pure line, what will be the phenotypic Autosomal dominant disorders are associated with genes found on autosome chromosomes that have a "spoiler" effect for the phenotype. In other words, if you inherit one spoiler dominant allele...
Genetics Pedigree Worksheet 1. Use the below pedigree chart to answer the following questions about dimples. The Dimple gene controls whether a person has dimples or doesn't have dimples. Dimples is dominant to no dimples. Place the genotypes of each individual below its symbol. O Dimples gene (D) Dimples is dominant to no dimples 12 13 14 A) How many family members have Dimples? B) What is the genotype of individual 3 and 4? C) Can cither individual #8 or...
. O . Using Pedigrees to hypothesize patterns of inheritance 5. For each of the pedigree charts on the following page, determine which pattern of inheritance most likely explains the observed pattern of traits in the family shown. Observe the general patterns in the pedigree charts on the following page o males vs females? parents with disease? Compare these patterns with the clues on the previous page to hypothesize a pattern of inheritance Based on this pattern of inheritance, use...
Look carefully at the pedigrees below and:
1) indicate whether the transmission appears autosomal or
sex-linked
2) indicate whether the transmission appears dominant or
recessive
3) provide at least two characteristics for each that support
your conclusion.
In general, the following characteristics suggest (but do not prove) specific inheritance patterns: Autosomal recessive inheritance: -affected individuals can be born to unaffected parents -if both parents are affected, all children are affected -observable effect of relatedness (consanguinity) -horizontal" inheritance: trait appears at...
Question 3 The following human pedigree shows a family affected by a specific disease. Assume that the individuals marked with an asterisk () do not carry any allele associated with the affected phenotype and that no other mutation spontaneously occurs. Also assume complete penetrance a) State the most likely mode of inheritance for this disease. Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive b) Write all possible genotypes of the following individuals in the pedigree. Use the uppercase...
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