Question

Can someone explain what the percentages mean, and what they stand for in this experiment?

SUBJECTS AND METHODS UCSF subjects University Subjects with RASopathies were ted at the Genetics California, San Francisco recrui Pathway NF/Ras Clinic and three national RASopathy family meetings (Chicago, Illinois, USA, July 2011; Berkeley, California, USA, July 2009; Orlando, Florida, USA, August 2013). Additional families were recruited at a UCSF NF Symposium (November 2011, and NE Inc., Children's Tumor Foundation, Noonan Foundation, CFC International, Costello Syndrome Family Support Network, and Costello Kids. criteria was reported diagnosis of CFO, CS, NS, or neurolo- NF1 by a medical geneticist, or diagnosis of NF1 gist. RASopathy subjects recruited at the UCSF clinic had initial or confirmed diagnoses by a medical geneticist (KAR). diagnosis was made using well-established criteria specified by the National Institutes of Health (NIH) Consensus Development Conference." Diagnosis of NF1, CFC, CS and NS recruited via meetings or RASopathy groups was by parent report, and diagnosis by molecular testing was reported for a subset of all NF1 (11%), NS (56%), CS (84%) and CFC (83%) subjects. All subjects had parents with fluency in English. Because not all subjects were diagnosed by study personnel or reported a known mutation, we performed main analyses with and without individuals with reported mutations, and deter- mined that inclusion of non-molecular diagnoses did not have a significant impact on our results (data not shown). Questionnaires were distributed in person or by mail. of 231 RASopathy probands, 108 have healthy full sibling participants. Siblings of RASopathy subjects were excluded if there was parental indication of possible RASopathy or ASD reported prior to data collection. This included two siblings with suspected NF1, and three siblings with ASDs. Two CFC probands in two different pairs of monozygotic twins were excluded. Participants less than 12 months old (n-1) were excluded, since questionnaire items pertain to behaviours typic. ally exhibited above this age. Participants less than 3 years old were excluded if more than two questionnaire items were blank

Answer 1

This is a clinical research study where specific study groups/subjects where taken for the study. There are some inclusion crietria mentioned in this study.So, here percentage means out of a specific set of patients who are included in the study This is the statistical representation of subjects/patients who are having this diagnosis.

Here , out of a set of patients:

11% is having NF1

56% is having diagnosis of NS

84% is having diagnosis of CS

83% is having diagnosis of CFC.