The enzyme-catalyzed reactions of Phase I metabolism bind oxygen, hydrogen, water, or amino acids to the lipophilic drug molecule to expose or introduce a hydroxyl (-OH), amino (-NH2), sulfhydryl (-SH), or carboxyl (-COOH) polar functional group, and thus, result in a modest increase in the parent drug's water solubility. These reactions include hydrolysis, reduction, and oxidation.
Select the correct metabolic phase l or phase Il reactions on the structure below. Sellos NCH,...
Using one of the reactions in this chapter, give the correct
starting material (A-L) needed to produce the following
structure.
- Write the letter corresponding to the correct starting
material in the space provided. If more than one of the starting
materials are used, write your answer as two letters. Example
"AB"
Name the type of reaction used by selecting the correct answer
from the choices provided. If the reaction is not an exact match
with any of the choices,...
select correct answer
In a heating or cooling curve, phase transitions occur when: Select the correct answer below: O temperature is rising O temperature is constant O temperature is falling O none of the above
provide the reaction conditions and the structure of the
correct products of the following reactions:
0.5 pts Question 2 (10 points) Provide the reaction conditions and the structure of the correct products of the following reactions: B RXN02B н®, сн,он heat А @ heat -H2O С NH The reaction code in the box is: RXN02B RXNO2A RXNO2C CE o
Which of the following metabolic reactions are possible for procainamide, shown below? O-dealkylation Hydrolysis Acetylation N-dealkylation ZI H2N
Use the reaction below and the options in A-E to answer questions 2 and 3. 2. (3 pt) Choose the correct initial intermediate that results when the epoxide reacts with NaSPh. 3. (3 pt) Choose the correct final structure after treatment with acidic water. 1. Na SP 2. Hz0+
Which of the following represents the phase change process of vaporization? Select the correct answer below: O using an icepack to keep drinks cool on a hot day O adding water to a bottle O the formation of fog on a cool morning O opening a bottle of perfume and immediately smelling the fragrance
Which statement about generation of reactive oxygen species below is NOT correct? Select one: a. Hydroxyl radical is formed from hydrogen peroxide O b. Hydroxyl radical can react with lipides O c. Hydroxyl radical can react with DNA and proteins O d. Hydroxyl radical react with hydrogen peroxide O e. Hydroxyl radical react with glutathione Check Estimate how many molecules of ATP is produced from complete oxidation of 1 molecule of tyrosine Answer: Check
Which statement about generation of reactive...
Question Choose the option below that demonstrates heterogeneous equilibrium Select the correct answer below O A reaction involving exclusively gaseous species O Areaction between solutes in aqueous solution O A reaction occurring in a liquid solution O A reaction involving a solid and a liquid FEE
Solve the compound Inequality 3 <x-13<12 Select the correct choice below and, if necessary, il in the answer box to complate your choice A. The solution set is Type your answer in interval notation Simplify your answer Use integers or fractions for any r The solution set is。 B.
Question 19 Identify the correct reactant necessary for the reaction shown below. Question 20 Which of the reactions shown below would be regioselective? (choose all correct answers) H-CI Bry, H,O Bra 1. BH3, H2O, THE 2. H2O2, OH, H2O