Question

2. Individuals lacking liver glucose-6-phosphatase accumulate a large amount of glycogen in the liver, while their blood glucose levels are only slightly increased when administered high doses of glucagon. What is the metabolic source of the glucose that causes the blood glucose levels to rise slightly? Justify your answer with key metabolic information regarding how glucagon affects cells, how the mutation changes cellular function, and how the glucose exits the cell.

Answer 1

• THE MAJOR SOURCE OF SUGAR IS FROM THE FOOD WE ATE MAINLY CARBOHYDRATES SUCH RICE AND THOSE WHICH QUICKLY CONVERTED INTO ENERGY LIKE BREAD,FRUITS,SUGAR ETC.PROTEIN CONTENT FOOD ALSO CONTAIN GLUCOSE.
• WHEN THIS GLUCOSE FLOW THROUGH BLOOD STREAM CALLED BLOOD GLUCOSE.
• INSULIN IS THE HORMONE RESPONSIBLE FOR THE CONVERSION OF THE FOOD GLUCOSE INTO ENERGY.
• INSULIN ALLOWS THE MUSCLE,LIVER,TISSUE TO TAKE THE GLUCOSE AND USE IT AS AN ENERGY SOURCE IN ORDER TO FUNCTION PROPERLY.
• GLUCOSE IN THE BODY IS STORED IN THE FORM OF GLYCOGEN.
• THE PANCREAS RELEASE TH GLUCAGON WHEN THE INSULIN IN THE BLOOD STREAM FALL TOO LOW.
• THE LIVER WILL CONVERT THE RELEASED GLUCAGON INTO GLUCOSE INTO THE BLOOD STREAM
• HIGH LEVEL OF GLUCOSE STIMULATE THE RELEASE OF INSULIN AND MAINTAIN THE LEVEL.
• THE GLUT1 AND GLUT3 IS LOCATED IN THE PLASMA MEMBRANE OF THE CELL