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Researchers have identified a gene in humans that (when mutant) causes severe dwarfism and mental retardation....

Researchers have identified a gene in humans that (when mutant) causes severe dwarfism and mental retardation. This disorder is inherited in an autosomal recessive manner, and the mutant allele is known to be a loss-of-function mutation. The same gene has been found on mice, although a mutant version of the gene has not been discovered in mice. To develop drugs and an effective therapy to treat this disorder, it would be extremely useful to have a mouse model of the disorder. In other words, it would be desirable to develop a strain of mice homozygous for a loss-of-function mutation in the mouse gene. Experimentally, how would you develop such a strain? List all of the steps necessary to accomplish this.

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we have to inject the mutated form of the gene in gamete via microinjection technique. after the injection gene recombination will take place and the functional gene has been replaced by the nonfunctional/mutated gene.

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