Question

which of the following is/are TRUE? (Select ALL that are TRUE.)
a) Lamin is an intermediate filament found in the nucleus, whereas keratin is an intermediate filament found in the cytoplasm of skin cells.

b) The disease progeria, premature aging in humans, is caused by mutation of a keratin gene.

c) When lamin is mutated, blisters form on the skin of mice because the skin cells are torn apart under stress.

d) Intermediate filaments form from assembly of coiled-coil dimers in which two alpha helical polypeptides are wound around each other.

e) The primary role of intermediate filaments is in providing mechanical strength to cells.

Answer 1

1. Lamin is an intermediate filament found in the nucleus, whereas keratin is an intermediate filament found in the cytoplasm of skin cells. True
2. The disease progeria, premature aging in humans, is caused by mutation of a keratin gene False
3. When lamin is mutated, blisters form on the skin of mice because the skin cells are torn apart under stress. False
4. Intermediate filaments form from assembly of coiled-coil dimers in which two alpha helical polypeptides are wound around each other. True
5. The primary role of intermediate filaments is in providing mechanical strength to cells True