Question

What is the likelihood that this individual inherited at least one non-functional allele predisposing him to cancer? Assume that every individual in thi spedigree that died of cancer was heterozygous with respect to a cancer-supressor gene Individual died from other cause Individual died from colon cancer Living individual Note: To make calculating the probability more manageable, assume that every person who died of cancer in this pedigree was genetically predisposed to cancer. Also, cancer is a complex condition, resulting from malfunctioning of many proteins encoded for by many genes. For this problem, however, you may treat this condition as though this is a single-gene trait Also, even though you technically don't know whether a person who died of another cause was not predisposed to cancer or not, for this problem, please assume that these individuals are NOTpredisposed to cancer. resulting from malfn't know whether aposed to cancer KEEP IN MIND THAT AN INDIVIDUAL CANNOTLIVE IF THEYAREHOMOZYGOUS RECESSIVE

In the space below, write your answer of the probability that this individual inherited 1 non-functional allele of the cancer-suppressor gene, predisposing him to cancer, but remembering that no individual that survives to birth can be homozygous for the recessive non-functional allele.Write your probability as a decimal fraction, starting with 0. and including 4 decimal places.

Answer 1

As the individual father has cancer, while his mother has a probability of 0.5% inheritance from her parents, the probability of this person predisposing to cancer will be 0.5%