Question

depaniak Bio 152-05 W17 Signed in as sama alsaady nze Homework scientific Thinking: Can Gene Expression Data Help Scientists Develop Persona 6 of 7 Part A Interpreting data Patients in Group I Patients in Group II In this activity, you will explore how DNA microarrays are being used as a tool forstudying-andpossibly treating-cancer. The data shown here were obtained from aDNA microarray study of gene expression pattems in 16 cancer patients. Although data for many more genes were obtained from the DNA microamay.only 12 specific genes of interest are shown. The data in the chart are color-coded as indicated by the key that appears below the chart Red represents high relative gene expression and blue represents low relative gene expression. Which of the following conclusions do the data support? Select all that apply. 3 2.5 2 -15 -1 -0.5 0 0.5 1.5 Normalized Expression Cells from patients in Group I carry different sets of genes than cells from patients in Group ll. n you were given microarray data from the cells of a new patient belonging to either Group I or Group ll, you would probably be able to tel which group the patent belongs to Gene K is more highly expressed in cells from patients in Group Ithan in oels from patients in Group II. For some genes, there is variation in the amount of mRNA present, even among patients in the same group. different set of genes is transcribed in cells from patients in Group Icompared to cells from patients in Group Il

Answer 1

a. If you were given microarray data from the cells of a new patient belonging to either group I or group II, you would probably be able to tell which group the patient belong to.

b. A different set of genes is transcribed in cells from the patients in Group) compared to the cells from the patients in Group II

c. For some genes, there is variation in the amount of mRNA present. Even among the patients of the same group.

The given microarray does not give a clear picture of the pattern of gene expression with respect to cancer. Patients of the same group have a different amount of mRNA for the same gene. Patients of one group should have the same pattern of gene expression. The DNA chip shows the expression of different genes in the cells of patients of group I and group II. This does not give information about the gene expression affected by cancer disease in the patients. Therefore, DNA chip from a different patient belonging to either group is required.