Question

Mycobacterium tuberculosis is an intracellular pathogen that grows within macrophages. Explain how the defense against this pathogen will be organized and what type of cells will be activated to fight the infection. Please include in your answer which MHC will be involved and what will follow after that (meaning what type of T cells will be engaged in the process)

Answer 1

Please look in the image for diagrammatic representation:

Cytotoxic T cells CD8 Tc Plasma Membrane ndogeneous Djantigen > e vesicle С умді босач Proteasome V Peptide sy. ER MHCL. with TAB TAP (Transporter associates untigen Processing, Processing of Endogeneous Antigen ter Associated vontigen Processing

Explanation:

First of all, the mycobacteria is digested which is present in the intracellular cytoplasm of antigen presenting cell. This is degraded by the proteasome into peptide chain. Now this peptide chain is transported to the endoplasmic reticulum via TAP protein. This peptide will attach to the MHC 1 in the endoplasmic reticulum. Then this will be transported to the Golgi body through vesicle. Then it will released to the the the outside so that the peptide containing MHC 1 receptor will attach to the plasma membrane. This peptide is recognised by cytotoxic T cells receptor. This leads to kill the antigen presenting cell via cytotoxic effect of Tc cells.

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