Question

Two genes are in strong linkage disequilibrium (LD) in a population, with a value of D...

Two genes are in strong linkage disequilibrium (LD) in a population, with a value of D =

0.16.

a. If the two genes are on different chromosomes and the population undergoes

random mating for two generations, what will the new values of D be after those

two generations? [Show calculations, but no written explanation necessary].

b.Would your answer to part (a) increase, decrease, or stay the same if the genes were on the same chromosome? Briefly explain why

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Answer #1

After n generations of random mating, the measure of association Dn is calculated as follows:

a.

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b.

If the two genes are on the same chromosome, the genes are said to be linked. The r value is less than 0.5 in this case, and D decreases more slowly. That means, the value of D increases if the two genes are on the same chromosome.

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