CLINICAL CHEMISTRY: Assuming carbon dioxide is kept at a constant partial pressure of 55 mmHg, and...
CLINICAL CHEMISTRY:
Assuming carbon dioxide is kept at a constant partial pressure of 55 mmHg, and your starting bicarbonate concentration is 22 mM; calculate how much excess bicarbonate it would require in order to raise the pH by .05 units.
Homework Answers
We know the relation between pH, conc of bicarbonate and parital pressure of CO2 is
pH = 6.1 + log [HCO3-] / 0.03pCO2
Given :
[HCO3-] = 22mM
pCO2 = 55mmHg
pH = 6.1 + log 22/ 0.03 X 55 = 7.22
Now we want to raise the pH by 0.05 units
new pH = 7.22 + 0.05 = 6.1 + log [HCO3-] / 0.03X pCO2
7.27 -6.1 = log [HCO3-] / 0.03 x pCO2
14.79 = [HCO3-] / 0.03 X pCO2
[HCO3-] = 24.40 mM
so excess bicarbonate needed = 24.40 - 22 mM = 2.4mM
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