The following compound undergoes an intramolecular Robinson annulation reaction consisting of a conjugate addition followed by...
please complete number 1 and 2 COMPLETELY The Robinson annulation is a classic example of what could be considered a paired reaction - that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could...
6) Predict missing starting compound and reagent in the following transformations (14 points). a. Robinson annulation reaction: Michael addition followed by aldol condensation O- NaOEt EtOH aldol condensation product Michael addition product aldol addition product
1. The Robinson annulation is a classic example of what could be considered a paired reaction- that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could happen. Analyze each one in terms of...
1. A Robinson annulation is a reaction that involves: (i) a Michael addition of an enolate onto an ,ß-unsaturated enone followed by (ii) an intramolecular aldol reaction. The molecule shown below (cyclohexenone X) can be made through two different Robinson annulation reactions. (A) Show the two different sets of starting materials (i.e. ketone 1 &a,p-unsaturated enone 1 and ketone 2 & a,B-unsaturated enone 2) for each Robinson annulation. Draw the reagents/reaction conditions. (B) Then pick one set and draw an...
Draw the major product of the following reaction that begins with a retro-aldol, followed by an intramolecular aldol condensation. (5 points) OH OH C7H100 H20 heat Create OscerSketch Answer 6 Determine and draw the structures of compounds A and B only. Do not draw the structure of compound X. Place each structure above its letter. HINT: Both A and B are esters. (10 points) LDA 1. compound B 1. NaOEt O= O= A Х -78 °C 2. H30* OEt 2....
Create OscerSketch Answer 5 Draw the major product of the following reaction that begins with a retro-aldol, followed by an intramolecular aldol condensation. (5 points) OH OH C7H100 H20 heat Create OscerSketch Answer 6
Create OscerSketch Answer 4 Draw the major product of the following intramolecular reaction. (5 points) OCH3 1. NaOCH3 oleh LOCH3 C3H1205 H3CO 2. H30* Create OscerSketch Answer 5 Draw the major product of the following reaction that begins with a retro-aldol, followed by an intra Р N 31
Draw the product that results from a Robinson Annulation reaction. . (4 points) Draw the product that results from a Robinson Annulation reaction. You are not required to show a mechanism. NaOH H2O/EVOH Robinson Annulation Product
1) Draw the major product of the following intramolecular reaction. 2) Draw the major product of the following reaction that begins with a retro-aldol, followed by an intramolecular aldol condensation. 3) Determine and draw the structures of compounds A and B only. Do not draw the structure of compound X. Place each structure above its letter. HINT: Both A and B are esters. 4) Draw a curved arrow mechanism for the following acid-catalyzed isomerization reaction. You must show all intermediates....
Draw the major product of the following reaction that begins with a retro-aldol, followed by an intramolecular aldol condensation. (5 points) OH OH C7H100 H20 heat