Draw the product that results from a Robinson Annulation reaction. . (4 points) Draw the product...
1. A Robinson annulation is a reaction that involves: (i) a Michael addition of an enolate onto an ,ß-unsaturated enone followed by (ii) an intramolecular aldol reaction. The molecule shown below (cyclohexenone X) can be made through two different Robinson annulation reactions. (A) Show the two different sets of starting materials (i.e. ketone 1 &a,p-unsaturated enone 1 and ketone 2 & a,B-unsaturated enone 2) for each Robinson annulation. Draw the reagents/reaction conditions. (B) Then pick one set and draw an...
4. Provide reasonable product structures. If you provide a mechanism for the Robinson Annulation a 10 pt bonus will be awarded. CD NaOEt و سلم . و Robinson Annulation OEt + Cu /
The following compound undergoes an intramolecular Robinson annulation reaction consisting of a conjugate addition followed by an aldol condensation. Draw the final product. No mechanism needed. Question 3 ( 5 points ) СН3 HO molargla H3C Create OscerSketch Answer 3 Question 4 Predict the product of the following reaction sequence. Draw the single main product structure only. ( 5 points ) H3C LDA (acid workup) Create OscerSketch Answer 4
please complete number 1 and 2 COMPLETELY
The Robinson annulation is a classic example of what could be considered a paired reaction - that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could...
Q 6 - Draw the mechanism for the following Robinson annulation reaction. Draw all the arrows to indicate movement of all electrons, write important lone pairs, all formal charges, and all products for each step. In the dotted box write the mechanistic element for each transformation. If a new chiral center is created in an intermediate or in the product indicate with an asterisk (*). 0:0: Racemic
1. The Robinson annulation is a classic example of what could be considered a paired reaction- that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could happen. Analyze each one in terms of...
1. Draw the major product(s) from the following Robinson Annulation reactions: Linda 2. Provide the starting materials that would yield the following Robinson Annulation products: Eto Na ETOH Eto Nat ЕОН EtO'Na* ELOH
Mechanism 5. The following reaction illustrates a Robinson annulation reaction. Give a complete stepwise mechanism for the reaction. [8 points OH
(6 points) Identify what reagents you would use to synthesize the following compound with a Robinson annulation reaction: (6 points) Propose a reasonable step-by-step mechanism for the following conversion: NaOH jd met H2O
10. (4 pts.) Show the product of the base-catalyzed Robinson Annulation reaction, using heat, between cyclohexanone and 3-buten-2-one. amide. Lacor told one student to add butanamide to a flask hu the addition of water as the