Mechanism 5. The following reaction illustrates a Robinson annulation reaction. Give a complete stepwise mechanism for...
The following reaction illustrates a Robinson annulation reaction. Give a complete stepwise mechanism for the reaction. The reaction.
For
the following Robinson annulation, provide a detailed stepwise
mechanism
& op wat KOH (cat.) on heat
Draw the product that results from a Robinson Annulation
reaction.
. (4 points) Draw the product that results from a Robinson Annulation reaction. You are not required to show a mechanism. NaOH H2O/EVOH Robinson Annulation Product
1. A Robinson annulation is a reaction that involves: (i) a Michael addition of an enolate onto an ,ß-unsaturated enone followed by (ii) an intramolecular aldol reaction. The molecule shown below (cyclohexenone X) can be made through two different Robinson annulation reactions. (A) Show the two different sets of starting materials (i.e. ketone 1 &a,p-unsaturated enone 1 and ketone 2 & a,B-unsaturated enone 2) for each Robinson annulation. Draw the reagents/reaction conditions. (B) Then pick one set and draw an...
please complete number 1 and 2 COMPLETELY
The Robinson annulation is a classic example of what could be considered a paired reaction - that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could...
7. MECHANISM: Give the complete stepwise mechanism to account for the following observation. Use curved arrows to show FLOW OF ELECTRONS. [9 points H-CI 8.RETROSYNTHETIC ANALYSIS Give a reasonable synthesis for the following compound from the indicated starting materials. You may use any other organic reagents or inorganic reagents you wish. The desired product for each reaction must be the MAJOR PRODUCT. Give the reactants, conditions (where appropriate), and products of each synthetic step but NO MECHANISMS. [6 points] OH...
3. Give the complete stepwise mechanism to account for the following observation. Use curved arrows to show the FLOW OF ELECTRONS. [5 points) OH H-CI
The following compound undergoes an intramolecular Robinson annulation reaction consisting of a conjugate addition followed by an aldol condensation. Draw the final product. No mechanism needed. Question 3 ( 5 points ) СН3 HO molargla H3C Create OscerSketch Answer 3 Question 4 Predict the product of the following reaction sequence. Draw the single main product structure only. ( 5 points ) H3C LDA (acid workup) Create OscerSketch Answer 4
please help me solve both of these!!
Write the complete stepwise mechanism for the acid catalyzed hydrolysis of the compound shown. Show all intermediates, indicate with curved arrows the movement of electrons and show all formal charges and lone pairs of electrons where relevant. Write the structure of the Michael addition product and the final Robinson annulation product when using the following starting materials. Hint: the dialdehyde is the Michael donor and the ketone is the Michael acceptor. Н Michael...
1. The Robinson annulation is a classic example of what could be considered a paired reaction- that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could happen. Analyze each one in terms of...