Homework Answers
Answer:- HMG-CoA reductase
Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate.
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Answer the following two questions. Statins, such as lovastatin. competitively inhibit one of the enzymes of...
Statins work to inhibit cholesterol synthesis by competing for the active site of an enzyme involved...
Statins work to inhibit cholesterol synthesis by competing for the active site of an enzyme involved in this pathway. What is the normal product of this enzyme? a. Squalene b. Mevalonate c. HMG CoA d. Isopenetnyl pyrophosphate
Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by...
Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by mimicking the structure of mevalonate. However, it is not this inhibition that directly lowers cholesterol levels in the blood. What enzymatic reaction does HMG CoA-reductase catalyze? What is important about this step of cholesterol synthesis? How can statins mechanistically cause a decrease in LDL cholesterol in the blood if it is not a direct effect of decreased cellular cholesterol synthesis?
Questions #1-2 refer to Atorvastatin, which is a competitive inhibitor of the rate limiting step of...
Questions #1-2 refer to Atorvastatin, which is a competitive inhibitor of the rate limiting step of cholesterol biosynthesis. 1. What is the downstream effect of treating cells with this competitive inhibitor? A. Atorvastatin decreases the Vmax of HMG CoA synthase. B. Atorvastatin decreases the KM of HMG CoA synthase. C. Atorvastatin decreases the Vmax of HMG CoA reductase. D. Atorvastatin decreases the KM of HMG CoA reductase. E. Atorvastatin increases the KM of HMG CoA reductase. 2. Mechanistically, how does...
Which of these enzymes is correctly paired with one of its immediate products? a. Glycogen phosphorylase:...
Which of these enzymes is correctly paired with one of its immediate products? a. Glycogen phosphorylase: Glucose 6-P b. Fatty acid synthase: Oleate c. HMG CoA Reductase: HMG CoA d. Debranching enzyme: Free glucose
1- Which of the following statements about cholesterol regulation is false? A) Insulin stimulates the production...
1- Which of the following statements about cholesterol regulation is false? A) Insulin stimulates the production of cholesterol. B) High intracellular cholesterol levels stimulate proteolysis of HMG-CoA reductase. C) High intracellular cholesterol levels inhibit the uptake of extracellular cholesterol. D) Glucagon stimulates the production of cholesterol. 2- Which statement is incorrect about the synthesis of fatty acids by fatty acid synthase in mammals? A) It uses FADH2 as a reductant of carbon-carbon double bonds. B) It uses NADPH as a...
I need help to answer these case study questions. its for cell biology class. Background: Researchers...
I need help to answer these case study questions. its for cell
biology class.
Background: Researchers were looking into the cause of a disease called Familial Hypercholesterolemia (FH) which is a genetic disorder that results in severely high serum cholesterol leading to blocked arteries and fatal heart attacks in diseases afflicted individuals. individuals Control fibroblast from normal individuals and fibroblast derived from FH individuals were grown in cell culture and tested as follows: Figure 2. In this study, fibroblast from...
Simvastatin (marketed under the name Zorcord), is a medicine for high blood cholesterol levels, see structure...
Simvastatin (marketed under the name Zorcord), is a medicine for
high blood cholesterol levels, see structure below. Simvastatin
belongs to the group of medicines called statins. Simvastatin acts
by blocking an enzyme, HMG-CoA reductase, which is found in the
cells where it is used in the cell's cholesterol production. This
means that the cells production of cholesterol decreases. The cells
then try to compensate for the decreased production by increasing
the absorption of cholesterol from the blood. This in turn...
I need help with answering these case study questions. its for cell biology class. Background: Researchers...
I
need help with answering these case study questions. its for cell
biology class.
Background: Researchers were looking into the cause of a disease called Familial Hypercholesterolemia (FH) which is a genetic disorder that results in severely high serum cholesterol leading to blocked arteries and fatal heart attacks in diseases afflicted individuals. individuals Control fibroblast from normal individuals and fibroblast derived from FH individuals were grown in cell culture and tested as follows: Figure 1. The question of whether cholesterol...
33-36) Use the list of enzymes below to answer questions 33 through 36: A. Galactase B....
33-36) Use the list of enzymes below to answer questions 33 through 36: A. Galactase B. Aspartate aminotransferase C. RNA primase D. Glucose reductase E. Steapsin F. Pyruvate dehydrogenase 33) Which of the enzymes, A, B, C, D, E, or F is most likely to be catalyst for a hydrolysis reaction PLACE ANSWER HERE 34) Which of the enzymes, A, B, C, D, E, or F is most likely to be digestive enzyme? PLACE ANSWER HERE 35) Which of the...
7. You have temporarily disabled all topisomerase enzymes in a eukaryotic cell. Answer the following questions....
7. You have temporarily disabled all topisomerase enzymes in a eukaryotic cell. Answer the following questions. (2.5 points) (A) How does a topoisomerase enzyme affect the chemical structure of DNA? (B) What cellular processes (covered in lecture) have you affected? Why does a topoisomerase enzyme work in each of those processes? Hint: consider all of the stages of the cell cycle! (C) How would your answer (in part B) change if the question specified that you had disabled topoisomerases in...
I need help to answer these case study questions. its for cell
biology class.
Background: Researchers were looking into the cause of a disease called Familial Hypercholesterolemia (FH) which is a genetic disorder that results in severely high serum cholesterol leading to blocked arteries and fatal heart attacks in diseases afflicted individuals. individuals Control fibroblast from normal individuals and fibroblast derived from FH individuals were grown in cell culture and tested as follows: Figure 2. In this study, fibroblast from...
Simvastatin (marketed under the name Zorcord), is a medicine for
high blood cholesterol levels, see structure below. Simvastatin
belongs to the group of medicines called statins. Simvastatin acts
by blocking an enzyme, HMG-CoA reductase, which is found in the
cells where it is used in the cell's cholesterol production. This
means that the cells production of cholesterol decreases. The cells
then try to compensate for the decreased production by increasing
the absorption of cholesterol from the blood. This in turn...
I
need help with answering these case study questions. its for cell
biology class.
Background: Researchers were looking into the cause of a disease called Familial Hypercholesterolemia (FH) which is a genetic disorder that results in severely high serum cholesterol leading to blocked arteries and fatal heart attacks in diseases afflicted individuals. individuals Control fibroblast from normal individuals and fibroblast derived from FH individuals were grown in cell culture and tested as follows: Figure 1. The question of whether cholesterol...
33-36) Use the list of enzymes below to answer questions 33 through 36: A. Galactase B. Aspartate aminotransferase C. RNA primase D. Glucose reductase E. Steapsin F. Pyruvate dehydrogenase 33) Which of the enzymes, A, B, C, D, E, or F is most likely to be catalyst for a hydrolysis reaction PLACE ANSWER HERE 34) Which of the enzymes, A, B, C, D, E, or F is most likely to be digestive enzyme? PLACE ANSWER HERE 35) Which of the...
7. You have temporarily disabled all topisomerase enzymes in a eukaryotic cell. Answer the following questions. (2.5 points) (A) How does a topoisomerase enzyme affect the chemical structure of DNA? (B) What cellular processes (covered in lecture) have you affected? Why does a topoisomerase enzyme work in each of those processes? Hint: consider all of the stages of the cell cycle! (C) How would your answer (in part B) change if the question specified that you had disabled topoisomerases in...
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