Low levels of certain types of estrogens in the body is the cause of several diseases in women. Alora is an FDA-approved drug for the treatment of symptoms associated with menopause and prevention of postmenopausal osteoporosis. The active ingredient in Alora is 17β-estradiol (Estradiol), an essential estrogen. The enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD) converts estrone into estradiol in the body. As a medicinal chemist, how would you synthesize estradiol from estrone in the laboratory?
Low levels of certain types of estrogens in the body is the cause of several diseases...