Question

For questions 41-43 consider the following scenarno: An overdose of a new system including vertigo, ataxia began within 15 minutes after oral administration of the drug. No metabolic breakdowih were found in the urine (pH was 5.5). However, a high concentratio the bile. The following information was obtained from the manufacturer. The drug is an orgai acid with a pk, of 6.4 and high lipid solubility and the drug is excreted by humans so that or the administered dose is eliminated in the urine in three days drug produced progressive effects referable to the central nervous a, somnolence, hypnosis and respiratory depression. These n of the agent was found in anic 41. The symptoms and physicochemical data indicate that the drug probably A. Readily passes through cell membranes, including the blood-brain barrier. B. Readily passes through cell membranes, but not the blood-brain barrier C. Readily penetrates from the circulation into the brain, but not into other organs. D. Can only diffuse into the glomerular filtrate. E. Cannot escape from th circulation. 42. The fact that it takes three days for % of the drug to be eliminated in the urine is best explained on the basis that the drug. A. Was rapidly excreted through the bile B. Undergoes little or no metabolism and is passively reabsorbed from the renal C. D. E. tubules Is deposited in bone Is actively reabsorbed from the renal tubules Does none of the above 43. The ratio of the unionized to the ionized form of the drug in plasma at pH 7.4 is 1:10 C. 10:1 100.1 E 1000.1

Answer 1