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A patient comes into clinic suffering from lack of energy and very low hemoglobin levels. You...

A patient comes into clinic suffering from lack of energy and very low hemoglobin levels. You run some tests and determine his red blood cells have a high level of phosphoenolpyruvate with little pyruvate produced and decreased ATP levels. You quickly deduce that he has a mutation in which glycolytic enzyme(s)?

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The final step of glycolysis is the conversion of Phosphoenol pyruvate to pyruvate by means of Pyruvate kninase. This step results in synthesis of 1 ATP along with pyruvate, The pyruvate is then converted to Acetyl coA by means of linked reaction which is then fed into the kreb's cycle for oxidative phosphorylation and subsequently ATP production. If the patient has high levels of phosphoenolpyruvate with little pyruvate produced and decreased ATP levels, it means that there is deficiency of the enzyme Pyruvate kinase, which will result in low levels of pyruvate and decreased TCA cycle and ETC and subsequently result in low ATP levels.

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