9. Is it possible that two single mutations could cause an oxytocin gene to mutate into a vasopressin
gene? If this is not possible explain why not.
Answer - Oxytocin and vasopressin are hormones both secreted by posterior pituitary .
Amino acid sequence of oxytocin is Met-Cys-Tyr-IIe-Gln-Asn-Cys-Pro-Leu-Gly
Oxytocin can be mutated to vasopressin if two single gene mutations occur and change the DNA sequence of
oxytocin as follows ;
9. Is it possible that two single mutations could cause an oxytocin gene to mutate into...
Inheritance and Mutations in a Single-Gene Disorder (10pts - all questions worth 0.5pts) Some diseases are caused by the environment. For example, exposure to chemicals or extremely bright lights can cause certain forms of blindness. But other forms of blindness are inherited, meaning that they are passed on from one generation to another. In this activity, you will learn about a young woman, Molly Troxel, who has an inherited form of blindness called Leber congenital amaurosis (LCA). The activity explores...
4. Mutations in the CX26 gene are a common cause of deafness. (You probably know some people at RIT who are deaf due to CX26 mutations.) CX26 codes for a gap junction protein expressed in the cochlea (inner ear); this protein forms a connection between cells and allows ions to pass between them Mutation 35delG is the most common cause of simple, genetic deafness in Caucasians, with a carrier rate of 1 in 35. If 1 in 5000 children in...
Explain how to identify causative mutations in single-gene Mendelian disorders using genetic markers, positional cloning and DNA sequencing eg hearing loss, neurofibromatosis, inflammatory bowel disease
Mutations in several different proteins could cause a nuclear cargo protein to be mistakenly transported into the ER. Please provide one example of a mutation in a protein that could cause this. i F B I U O EE & QiLearn Video A. Protein (or type of protein) - I B. Effect of mutation -
In genetic analysis, the test is used to determine whether two recessive mutations that cause similar phenotype are allowed of the same gene. DNA strands are said to be because the phosphate linkages in the backbones run in opposite directions. An arrangement of metaphase chromosomes according to their and centromere placement is called a An enzyme called can produce a complementary DNA strand from an RNA template
Which of the following adenines could you mutate to create a silent transversion mutation? 5'-ATG GGA TGG CAC CTG-3' Answer: A to G or C to T -I don't really understand why this is the answer. I get that the adenine you will use is the one in the GGA, since it is the third codon it will cause a silent mutation. But why does the answer key say A to G or C to T? Shouldn't it say A...
8. Two approaches for correcting single-gene defects are gene therapy such as is discussed in Section 3-5D (Base Excision Repair, Nucleotide Excision Repair, and Mismatch Repair) and the CRISPR–Cas9 system. Explain why the CRISPR–Cas9 approach can potentially provide more complete restoration of normal tissue function than gene therapy. (5pts)
Which of the following mutations would cause the most harmful effect: 1) a single base insertion near the beginning of the coding sequence or 2) a three base deletion towards the end of the coding sequence.
For rs182549 and rs4988235 within the lactose intolerance gene MCM6, what is one possible way that these mutations could have arisen? Why is depth coverage important? A complete answer will include DNA replication in a cell compared to in a sequencing reaction. a. What are some factors that could affect SNPs being preserved in a specific population? b. What is the common explanation for a mutant phenotype’s geographical distribution?
3. The following table lists several possible null (gene-inactivating) mutations in the lac operon system. Fill in the expected outcomes from each of these. Effect on lacZ expression Mutant Lacl Laco Placzya (promoter)