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What effect does Cyanide have on NAD+ and NADH production in Complex IV of the Electron...

What effect does Cyanide have on NAD+ and NADH production in Complex IV of the Electron Transport Chain? Why would cyanide cause High NADH concentrations and low NAD+ concentrations?

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cyanide will bind with the heam group of the cytochrome protein and stop the conversion of NADH to NAD+ (electron transfer). hence ATP will not be generated. because NADH, due to cytochrome protein inactivation, will not transfer electron further and hence accumulate in high quantity as compare to NAD+.

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