Question

Summary Information Bel ow In Your Own Words Dengue is endemic in more than 100 countries and it is estimated that annually above 390 million infecti ons occur globally. During the period between 1996-2015, a massive increase of more than 500 per cent has been recorded in number of dengue cases reportedin India. Till date, there are no specific globally accepted treatments for dengue fever in any system of medicine. Dengue does not cause very high mortality if properly handl ed and is currently being managed by clinicians through various adjuvant and alternative therapeutic options. Various plant based preparations have been used in different parts of India for combating dengue and are simultaneously also being scientifically validated by researchers. However, number of such scientific validation studies on phytomedicines are very less in India Out of twenty-two plants reported against dengue, only four have been studied scientifically. Azadirachta indica, Carica papaya Hippophae rhamnoides and Cissampelos pareira extracts were found effective and demonstrated improvement in clinical symptoms and directinhibitory effect on dengue virus. C. papaya dlinical trial showed increase in platelet count and faster recovery. These plants may be explored further as probable can didates for drug discovery against dengue. There is a need to search more such herbal fomulations, which are being practiced at local level, document properly and validate them scientifically to confirm efficacy, mechanistic action and safety, before use. The herbal fomulations being used by communiti es are the low hanging fruits which may provide alternative or adjuvant therapy if proper validati on, value addition and product development steps are foll owed. This paper aims to review the recent status of dengue cases, deaths and evolving curative herbal solutions adapted and reported from India to combat the disease.

Answer 1

Dengue fever is considered an endemic infectiuous disease that widespread all over the world.In India, the number of cases have increased dramatically between 1996- 2015

The risk of mortality of this illness is low if it is properly treated. Nowadays, many alternative therapeutic and adyuvants are options of treatment. Most of them are consider phytomedicines because are obtained from plant extracts.The point is that few of them are validated scientifically ( 4 of 22 compounds). These 4 compounds were found effective in controlling the symptoms and also showed inhibitory effects over virus replication in preliminary studies.

So ,in the futur, this drugs could be considered as alternative therapeutics agents , but further scientific studies must be done in order to validated them