Homework Answers
Q1: Please see square boxed ones for better understanding how cell signalling works and we will find the answer during a cell signal GCPR (G-coupled protein receptor).
Q3: Steroid hormones are derived from cholesterol and are lipid-soluble molecules. Steroid harmones are small and hydrophobic, they can diffuse directly across the plasma membrane into the cell, where they interact with internal receptors. In cell only they will bind not in the plasma membrane.
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Question 1 (1 point)d A molecule that binds to a protein receptor in the plasma membrane,...
Choose whether each protein is an integral membrane protein or a peripheral membrane protein. A receptor...
Choose whether each protein is an integral membrane protein or a peripheral membrane protein. A receptor (eg, a G-protein coupled receptor or a receptor tyrosine kinase) [Choose] A protein with a lipid covalently attached [Choose ] A voltage-gated transporter (Choose A kinase that binds to the polar head groups of membranes and phosphorylates them [Choose] A protein that binds to the intracellular region of a receptor protein. [Choose ]
If the pinsulin receptor, a, example of an integral membrane protein, is cotranslationally inserted into the...
If the pinsulin receptor, a, example of an integral membrane protein, is cotranslationally inserted into the ER membrane with the N-terminus on the cytosolic side of the membrane and the C-terminus in the lumen of the ER, which side of the protein would you expect to bind to the ligand, pinsulin, when the protein is found on the cell surface? A. N-terminal end of the protein will bind pinsulin B. Neither will bind to a ligand because both ends of...
The nicotinic acetylcholine receptors are transmembrane protein found in the plasma membrane of human neurons. You...
The nicotinic acetylcholine receptors are transmembrane protein found in the plasma membrane of human neurons. You are studying a member of the receptor family that is glycosylated. Based on this information, answer the following questions: Was the receptor synthesized on cytosolic ribosomes or ER-bound ribosomes? Justify your answer Describe the cellular path that the receptor likely took from synthesis to the plasma membrane.
Place the following events in Receptor Tyrosine Kinase signaling in order from the point when the...
Place the following events in Receptor Tyrosine Kinase signaling in order from the point when the RTK binds it ligand. A.) An SH2 domain proteins is recruited to phosphotyrosine residues B.) cytoplasmic tails of the RTKs cross-phosphorylate C.) RAS-GEF catalyzes GTP exchange on RAS D.) Receptors dimerize in the plasma membrane
B. The plasma memibrane buds off exosomes from the surface C. They come from the nucleus theough the D. Specialized vesicles from E. Late endosomes fuse from the surface mitochondria bud off and...
B. The plasma memibrane buds off exosomes from the surface C. They come from the nucleus theough the D. Specialized vesicles from E. Late endosomes fuse from the surface mitochondria bud off and are secreted with the plasma membrane and release their content is a minus end directed motor on microtubules A. Dynein B. Myosin C. Kinesin D. Motorin .E. All of the above 19. M ovement of molecules from one side of an epithelial Iayer so the oher is...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly. The activated r...
Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly. The activated receptor stimulates a G protein, which opens a K channel in the plasma membrane, as shown in the figure below. Which of the following would enhance this effect of the acetylcholine? plasma membrane closed K' channel GTP Pr complex activated α subunit K CHANNEL open K'channel OPENING EXTRACELLULAR SPACE CYTOSOL GTP G-PROTEIN INACTIVATION K" CHANNEL CLOSING closed K' channel rt inactive G protein GOP...
An adrenaline receptor is a transmembrane protein that has a signaling domain on the inside of...
An adrenaline receptor is a transmembrane protein that has a signaling domain on the inside of the cell that is activated after adrenaline binds to it on the outside of the cell. Which direction does the signaling domain face when it is in the Golgi apparatus for processing? A. Extracellular B. Cytosol C. Nucleus D. Lumen
The ability of a single signal molecule to bind to a receptor and trigger several signal...
The ability of a single signal molecule to bind to a receptor and trigger several signal transduction pathways simultaneously: a. Is common to all plasma membrane receptor proteins b. Does not occur in animals c. Is a key feature of the receptor tyrosine-kinase system d. Uses a diacylglycerol-mediated pathway
Question 11 (1 point) Which of the following options most closely resembles the typical pathway of...
Question 11 (1 point)
Which of the following options most closely resembles the
typical pathway of a molecule like testosterone?
Question 11 options:
Binds to steroid hormone receptor-> receptor
is activated -> many kinases are activated -> complex signal
cascade-> cellular response
Enters cell -> binds to peptide hormone
receptor -> receptor enters nucleus -> change in
transcription
Enters cell -> binds to steroid hormone
receptor -> receptor enters nucleus -> change in
transcription
Binds to peptide hormone receptor ->...
Choose whether each protein is an integral membrane protein or a peripheral membrane protein. A receptor (eg, a G-protein coupled receptor or a receptor tyrosine kinase) [Choose] A protein with a lipid covalently attached [Choose ] A voltage-gated transporter (Choose A kinase that binds to the polar head groups of membranes and phosphorylates them [Choose] A protein that binds to the intracellular region of a receptor protein. [Choose ]
B. The plasma memibrane buds off exosomes from the surface C. They come from the nucleus theough the D. Specialized vesicles from E. Late endosomes fuse from the surface mitochondria bud off and are secreted with the plasma membrane and release their content is a minus end directed motor on microtubules A. Dynein B. Myosin C. Kinesin D. Motorin .E. All of the above 19. M ovement of molecules from one side of an epithelial Iayer so the oher is...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly. The activated receptor stimulates a G protein, which opens a K channel in the plasma membrane, as shown in the figure below. Which of the following would enhance this effect of the acetylcholine? plasma membrane closed K' channel GTP Pr complex activated α subunit K CHANNEL open K'channel OPENING EXTRACELLULAR SPACE CYTOSOL GTP G-PROTEIN INACTIVATION K" CHANNEL CLOSING closed K' channel rt inactive G protein GOP...
Question 11 (1 point)
Which of the following options most closely resembles the
typical pathway of a molecule like testosterone?
Question 11 options:
Binds to steroid hormone receptor-> receptor
is activated -> many kinases are activated -> complex signal
cascade-> cellular response
Enters cell -> binds to peptide hormone
receptor -> receptor enters nucleus -> change in
transcription
Enters cell -> binds to steroid hormone
receptor -> receptor enters nucleus -> change in
transcription
Binds to peptide hormone receptor ->...
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