Question

10.Which statement regarding the transcriptional regulation of PEP carboxykinase is false

A. The promoter region of the PEP carboxykinase gene has binding sites for more than a dozen transcription factors

B. Transcription and degradation are the primary means of regulating PEP carboxykinase gene

C . A sterol regulatory binding element protein decrease expression of the PEP carboxykinase gene

D. Insulin increase expression of the PEP carboxykinase gene

11. Glycogenesis -

A. Occurs only in the liver and muscle

B. Begins the production of new glycogen molecule with the reactions of glycogenin

C. Involves the action of glycogen debranching enzyme

D. Involves transfer of glucose from CDP - glucose to a non reducing end of a glycogen chain

1. Glycogenolysis _

A. Is used by muscle to increase blood level

B. Releases glucose 1-phosphate from the reducing end of glycogen molecules

C. Is mostly the result of the actions of glycogen hydrolase

D. Product mostly glucose 1-phosphate, but also glucose in the ER of hepatocytes

Which statement regarding glycogen phosphorylase is false

A. In the liver, glucagon indirectly stimulates glycogen phosphorylase activity

B. In muscle epinephrine indirectly stimulates glycogen phosphorylase activity

C. In muscle Ca 2+ stimulates dephosphorylation of glycogen phosphorylase

D. Glycogen phosphorylase b is less active than glycogen phosphorylase a

1. Glycogen synthase kinase 3-

A. Phosphorylates glycogen synthase only after glycogen synthase has been phosphorylated by another kinase.

B. Is indirectly stimulated insulin

C. Functions only in regulation of glycogen synthase

D. Phosphorylates casein kinase II

Hormonal regulation of glycogen metabolism in muscle -

A. Results in stimulation of glycogen synthesis when blood glucose level are low

B. Does not involve the actions of cAMP

C. Is primarily through the actions of insulin and glucagon

D. Involves phosphorylation and dephosphorylation of Gm

Answer 1

10. D

PEP carboxykinase expression is induced by glucagon, catecholamines and glucocorticoids during periods of fasting and in response to stress, but is dominantly inhibited by glucose-induced increases in insulin secretion upon feeding. Therefore, insulin decreases the PEP carboxykinase gene.

11.A

The extra glucose is converted to glycogen in the liver and muscle.