A woman with sickle cell trait is four months pregnant, and knows that her fetus is...
A woman with sickle cell trait is four months pregnant, and knows that her fetus is homozygous for the βs gene. She wants to visit her mother in Denver but worries whether the decrease in oxygen pressure there will cause the fetus to have a sickle cell crisis. What do you tell her?
Homework Answers
Answer:
Decrease in oxygen pressure will have no effect on the fetus. Hence, she can visit her mother without any worries.
Explanation:
Adult hemoglobin is composed of 2 α (alpha) and 2 β (beta) subunits, fetal hemoglobin is composed of 2 α subunits and 2 γ (gamma) subunits, and is commonly denoted as α2γ2.
Fetal hemoglobin has more affinity for oxygen than adult hemoglobin which is necessary during intra uterine life.
However, fetal hemoglobin is replaced by adult hemoglobin within 6 months of birth as it is no longer required.
Sickle cell disease manifest only after formation of adult hemoglobin because HbS is a mutant variation of adult hemoglobin while the HbF(fetal hemoglobin) is completely normal.
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