Question

1. A) What are some diseases associated with Phosphoglycerate Kinase?

   B) What are some of the metabolic consequences in these diseases?

C) What are the symptoms and treatments?

Please explain and answer correctly. Will Rate!

Answer 1

A. Some of the diseases associated with Phosphoglycerate kinase are- Hemolytic anemia, mental disorder, and Muscle myopathy. Phosphoglycerate kinase gene is located in the X chromosome, as a result, Phosphoglycerate kinase deficiency disorder is an X-linked rare genetic disorder mostly suffering male.

B. Phosphoglycerate kinase enzyme is an important enzyme involved in the glycolysis pathway. The enzyme catalyzes the transfer of a phosphate group to ADP from 1,3-bisphosphoglycerate forming ATP, the form of cellular energy. The deficiency of Phosphoglycerate results in an inability for the proper breakdown of Glycogen, the stored form of energy, resulting in low energy levels in patients.

C. Some of the symptoms associated with Phosphoglycerate kinase are- lower level of circulating RBC, intellectual disability, impaired ability to communicate, exercise-induced pain, muscle cramps and stiffness, spleen enlargement and paralysis.