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describe how an enzyme that is destined for the lysosome gets synthesized and transported

describe how an enzyme that is destined for the lysosome gets synthesized and transported
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Answer #1

Lysosome = Digestive bags of the cell = Suicidal bags of the cell
They contain several hydrolytic enzymes responsible for the breakdown of several biomolecules.

Lysosomal targeted proteins are synthesized on ribosomes attached to the ER (RER).
The nascent peptide is released into the ER lumen for proper folding and post-translational modifications.
The nascent peptide is then transported to the cis-Golgi where it further undergoes post-translational modifications.
Proteins destined for a lysosome are tagged with a mannose-6-phosphate label.
The functional proteins and packed into vesicles and fuse with the lysosomes.

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