Describe how inhibition of the plasma membrane Na/K ATPase affects Glucose absorption:
Glucose absorption :-
• Glucose, is transported into the epithelial cells of the
intestine by active transport, via a sodium dependant transporter
called SGLT 1.
• Sodium-glucose linked transporter (SGLT) activity is maintained
by sodium concentration gradient.
• Na/K ATPase pumps sodium out to cell by active transport and
creates low concentration of sodium. This low concentration of
sodium in cell drives activity of SGLT, now glucose transported
into cell by symport with sodium down to the concentration gradient
of sodium. (*Sodium is transported in direction of concentration
gradient with glucose).
If Na/K ATPase is inhibited then :-
• No pumping of sodium out to cell.
• High concentration of sodium in cell.
• No movement of sodium along with glucose from outside to
inside.
• Glucose absorption is stopped.
So, Na/K inhibition will decrease or stop the glucose absorption.
Describe how inhibition of the plasma membrane Na/K ATPase affects Glucose absorption:
Na^+/K^+ ATPase (sodium potassum adenosine triphosphatase) is found in the plasma membrane and catalyzes the exchange of sodium and potassium ions across the membrane. Sort the following statements about the transport system as either true or false.
Question 33 2.5 pts The Na+-K+ ATPase transporter found in the plasma membrane of most animal cells gets its energy from: ATP hydrolysis The electrochemical gradient across the membrane O Co-transport of H+ into the cell None are correct, this transporter functions by facilitated diffusion All are correct
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You have isolated the Na/K-ATPase in a semi-purified membrane system. Given higher concentrations of Na' out and higher K inside, addition of ATP to the inside leads to increases of Nat olutside and Kt inside as expected. If instead, you add the ATP to the outside of the membrane, you don't see any change in the ion levels. Why? • ATP acts as an irreversible inhibitor of the Na/K-ATPase if it binds on the exterior side. The active site for...
imumseinratio that can be 2. Calculate the maximum (glucose]out achieved by the plasma membrane Na*-glucose symporter of an epithelial cell when [Na']n 12 mM, [Nalout 145 mM, the membrane potential is -50 mV (inside negative), and the temperature is 37 °C Apical surface Basal surface Intestinal Blood lumen 2 K* Microvili Epithelial cell 3 Na+ Na"K+ ATPas Glucose Glucose Glucose uniporter GLUT2 (facilitates Na -glucose symporter (driven by high extracellular Na I downhill efflux) imumseinratio that can be 2. Calculate...
The function of Na+K+ ATPase in a cell membrane of cultured cells is being investigated. The cell is then supplied with an analog of ATP (ATV, adenosine tri canada the) this binds to the protein but there is no hydrolysis. What would be the affect of this drug on the transporter
Describe how the Na+ –K+ ATPase manages to cycle through its various states unidirectionally (pumping 3Na+ ions out of and 2K+ ions into the cell per cycle) and how the pump discriminates between Na+ and K+ ions (which bind to the same site!).
Question 1 Which of the following are likely to diffuse through the plasma membrane? glucose K+ Cl- H20 Na+ CO2 02 lipid Question 4 Which is(are) true about transport across the membrane? Channels can perform either active or passive transport Charged molecules move according to their electrochemical gradients Movement of an ion down its gradient requires energy Transporters are faster but less selective than channels Question 6 In the coupled transport of Na+ and glucose, the transporter O is an...
Describe how the Na+ –K+ ATPase manages to cycle through its various states unidirectionally (pumping 3Na+ ions out of and 2K+ ions into the cell per cycle) and how the pump discriminates between Na+ and K+ ions (which bind to the same site!).