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Describe how inhibition of the plasma membrane Na/K ATPase affects Glucose absorption:

Describe how inhibition of the plasma membrane Na/K ATPase affects Glucose absorption:

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Answer #1

Glucose absorption :-
• Glucose, is transported into the epithelial cells of the intestine by active transport, via a sodium dependant transporter called SGLT 1.
• Sodium-glucose linked transporter (SGLT) activity is maintained by sodium concentration gradient.
• Na/K ATPase pumps sodium out to cell by active transport and creates low concentration of sodium. This low concentration of sodium in cell drives activity of SGLT, now glucose transported into cell by symport with sodium down to the concentration gradient of sodium. (*Sodium is transported in direction of concentration gradient with glucose).

If Na/K ATPase is inhibited then :-
• No pumping of sodium out to cell.
• High concentration of sodium in cell.
• No movement of sodium along with glucose from outside to inside.
• Glucose absorption is stopped.

So, Na/K inhibition will decrease or stop the glucose absorption.

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