HER1 signaling is triggered by HER1 monomers each binding its ligand followed by homodimerization and autophosphorylation....
HER1 signaling is triggered by HER1 monomers each binding its ligand followed by homodimerization and autophosphorylation. How do HER2/HER3 heterodimers initiate signaling?
A. Neither HER2 nor HER3 bind ligands, but can form heterodimers that activate HER2 kinase which then autophoshorylates.
B. Neither HER2 nor HER3 bind ligands, but can form heterodimers that activate HER3 kinase which then autophoshorylates.
C. HER2, but not HER3 binds its ligand, causing it heterodimerize with HER3. This activates HER3 kinase which then autophosphorylates.
D. HER2 and HER3 each bind its ligand followed by heterodimerization and activation of both kinases which then autophosphorylate.
E. HER3, but not HER2 binds its ligand, causing it heterodimerize with HER2. This activates HER2 kinase which then autophosphorylates.
Homework Answers
Add Answer to:
HER1 signaling is triggered by HER1 monomers each binding its
ligand followed by homodimerization and autophosphorylation....
Match the hormone to the mechanism of signaling. neurotransmitter Acetylcholine [ Choose ] ...
Match the hormone to the mechanism of signaling. neurotransmitter Acetylcholine [ Choose ] binds to a receptor tyrosine kinase, causing dimerization and activation binds to a histone acetylase to activate transcription binds a nuclear receptor which is a DNA binding protein opens a ligand-gated ion channel in skeletal muscle steroid like progesterone [ Choose ] binds to a receptor...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
3. 7TM receptors are found everywhere throughout the body, and they all bind different ligands. One...
3. 7TM receptors are found everywhere throughout the body, and they all bind different ligands. One such receptor binds the ligand shown below. Notice this molecule is in a cis form: 9% After it binds in, it gets isomerized to the trans form: CH This conversion activates the receptor and sets off a signal cascade. Hypothesize why this conversion would activate a signal cascade (what needs to happen for the cascade to start)? a. After the conversion, the newly formed...
9. What happens when a trimeric G a. Ga separates from b. GB separates from the...
9. What happens when a trimeric G a. Ga separates from b. GB separates from the GaG protein is activated by the GpGy dimer dimer d. Ga, Gp, and Gy separate from each other e. The trimeric G protein localizes to the c. Gy separates from the GaGß dimer t nuceus se the folowing list to answer questions 10-13.Answers can be used more than once a. Endocytosis followed by degradation in lysosomes tqitination mediated by SOCS followed by degradation by...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented below. Activation of the signaling pathway results in a cell secreting a neurotransmitter through exocytosis. Activated - Activated adenylyl receptor cyclase GTP АТР CAMP Active G protein Protein- kinase A Inactive Active Protein targets Phosphate group A. Different steps in a signaling pathway can amplify the initial signal of one ligand binding to one receptor. Choose one step in the pathway below that results...
QUESTION 1 When cells stimulate other cells at long distances, it is referred to as: paracrine...
QUESTION 1 When cells stimulate other cells at long distances, it is referred to as: paracrine loops autocrine loops synaptic signaling endocrine signaling 1 points QUESTION 2 What region of a protein binds phosphorylated serines & tyrosines on another protein? SH2 domain ligand cAMP receptor monomers 1 points QUESTION 3 Activation of a serpentine receptor can lead to: cAMP generation GTP-binding of G proteins activation of Protein Kinase A all of the above 1 points QUESTION 4...
Last guy got it wrong - Thank you. 2. You discover a signal transduction pathway that...
Last guy got it wrong - Thank you.
2. You discover a signal transduction pathway that regulates actin polymerization. SigC is the ligand, which binds to and activates a receptor tyrosine kinase (RTK). Activation of the RTK leads to the activation of the Ras protein, which then activates the protein kinase PK1 that phosphorylates the RingA protein on S34. When SigC plasma membrane phosphorylated, RingA binds EXTRACELLULAR to the gene regulatory SPACE inactive Ras protein activated Ras protein protein, AP1....
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein...
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
What is the correct answer? And please explain in 2-3 sentences on why it is the...
What is the correct answer? And please explain
in
2-3 sentences on why it is the correct answer for each,
thank you !
15. Which statement below about the interconversion of the alpha and beta anomers of D-glucopyranose is true? The interconversion requires an enzyme called an isomerase The interconversion is spontaneous in water because the acetal functionality is labile The interconversion is spontaneous in water but is slow which is why we typically draw glucose having one anomeric form...
€ → C .ap2020.collegeboard.org/Praott-aa857320- glucagon (a) A cell where PKB is always active has a mutation...
€ → C .ap2020.collegeboard.org/Praott-aa857320- glucagon (a) A cell where PKB is always active has a mutation that results in the permanent activation of GSK3. Based on the information in Figure 2, predict the effect of this mutation on the activity of glycogen synthase. (b) Justify your prediction in part (a). Describe the process that results in the activation of multiple copies of PKB in response to the binding of a single molecule of insulin to its receptor. (d) Explain why...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
3. 7TM receptors are found everywhere throughout the body, and they all bind different ligands. One such receptor binds the ligand shown below. Notice this molecule is in a cis form: 9% After it binds in, it gets isomerized to the trans form: CH This conversion activates the receptor and sets off a signal cascade. Hypothesize why this conversion would activate a signal cascade (what needs to happen for the cascade to start)? a. After the conversion, the newly formed...
9. What happens when a trimeric G a. Ga separates from b. GB separates from the GaG protein is activated by the GpGy dimer dimer d. Ga, Gp, and Gy separate from each other e. The trimeric G protein localizes to the c. Gy separates from the GaGß dimer t nuceus se the folowing list to answer questions 10-13.Answers can be used more than once a. Endocytosis followed by degradation in lysosomes tqitination mediated by SOCS followed by degradation by...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented below. Activation of the signaling pathway results in a cell secreting a neurotransmitter through exocytosis. Activated - Activated adenylyl receptor cyclase GTP АТР CAMP Active G protein Protein- kinase A Inactive Active Protein targets Phosphate group A. Different steps in a signaling pathway can amplify the initial signal of one ligand binding to one receptor. Choose one step in the pathway below that results...
Last guy got it wrong - Thank you.
2. You discover a signal transduction pathway that regulates actin polymerization. SigC is the ligand, which binds to and activates a receptor tyrosine kinase (RTK). Activation of the RTK leads to the activation of the Ras protein, which then activates the protein kinase PK1 that phosphorylates the RingA protein on S34. When SigC plasma membrane phosphorylated, RingA binds EXTRACELLULAR to the gene regulatory SPACE inactive Ras protein activated Ras protein protein, AP1....
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
What is the correct answer? And please explain
in
2-3 sentences on why it is the correct answer for each,
thank you !
15. Which statement below about the interconversion of the alpha and beta anomers of D-glucopyranose is true? The interconversion requires an enzyme called an isomerase The interconversion is spontaneous in water because the acetal functionality is labile The interconversion is spontaneous in water but is slow which is why we typically draw glucose having one anomeric form...
€ → C .ap2020.collegeboard.org/Praott-aa857320- glucagon (a) A cell where PKB is always active has a mutation that results in the permanent activation of GSK3. Based on the information in Figure 2, predict the effect of this mutation on the activity of glycogen synthase. (b) Justify your prediction in part (a). Describe the process that results in the activation of multiple copies of PKB in response to the binding of a single molecule of insulin to its receptor. (d) Explain why...
Most questions answered within 3 hours.
-
Assume that an online movie subscription service currently has
7.4 million customers and that its retention...
asked 46 seconds from now -
calculate the orbital frequency for the ground state
orbit of hydrogen atom (k=9x10^9 m/f e=1.60x10^-19
m=9.11x10^-31kj
asked 2 minutes ago -
(Q#1) Hydroxyapatite has the formula
Ca5(PO4)3(OH) and is the main
mineral component of dental enamel and...
asked 18 minutes ago -
How do e-mail, instant messaging, and Voice over Internet
Protocol work, and how is information using...
asked 15 minutes ago -
Feet-First Industries plans to sell 7,750 sleds at $85 each in
the coming year. Variable cost...
asked 20 minutes ago -
A spacecraft utilized Earth's gravity and increasing large
orbital paths around Earth to minimize the use...
asked 22 minutes ago -
What is the net rate of radiating heat of a 406-m2 black roof on
a night...
asked 32 minutes ago -
9) A rectangular channel 8 feet wide carries 2.5 ft/s of water
at a depth of...
asked 36 minutes ago -
A device that is used to measure wind speed is called an
anemometer. When it measures...
asked 37 minutes ago -
Cathode ray tubes (CRTs) used in old-style televisions have been
replaced by modern LCD and LED...
asked 40 minutes ago -
An electron with a speed of 1.7 × 107 m/s moves
horizontally into a region where...
asked 51 minutes ago -
A resistor has a value of 96 ΩΩ and if the base current is 20 A...
asked 49 minutes ago