3. 7TM receptors are found everywhere throughout the body, and they all bind different ligands. One...

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3. 7TM receptors are found everywhere throughout the body, and they all bind different ligands. One such receptor binds the ligand shown below. Notice this molecule is in a cis form: 9% After it binds in, it gets isomerized to the trans form: CH

This conversion activates the receptor and sets off a signal cascade. Hypothesize why this conversion would activate a signal cascade (what needs to happen for the cascade to start)? a. After the conversion, the newly formed trans molecule breaks its bond and leaves the receptor. Why is this necessary? b. If the signal needs to be stopped real fast, what kind of binding would you expect the receptor and the ligand to have and why? c.

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