Question

What signal transduction pathway is utilized almost exclusively by interferons?

Jak-STAT pathway

cAMP-PKA pathway

Ras-MAPK pathway

NF-kB pathway

Gluconeogenesis pathway

Answer 1

Answer: Jak- STAT pathway

Explanation: Interferons are cytokines released/secreted by host cell in response to pathogens such as virus. There Interferons are classified in to three type based on receptors i.e type-I, type-II and type-III

Jak- STAT pathway stands for Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. It play a major role immune response of the body, mainly triggered/activated by Interferons.  

When a virus/pathogen is attaches to T cell or a virus infected leucocytes would release the interferons, these interferons would bind to respective receptor and activates JAK, the activated kinase phosphorylates STAT initiate various immune responses such as anti-viral, anti-cancer, and immunoregulatory effects.