Question

What does the phrase "epigenetic transgenerational inheritance of disease susceptibility" mean?

Question options:

	a) changes to factors that affect gene expression, that are passed down to offspring, and affect whether or not offspring will get a particular disease
	b) changes to DNA sequences, that are passed down to offspring, and affect whether offspring will get a particular disease
	c) changes to factors that affect gene expression, that can be passed on from offspring to parents, and affect whether or notparents will get a particular disease
	d) changes to DNA sequences, that are passed down to offspring, and will determine whether an offspring will get a particular disease
	e) changes to factors that affect gene expression, that are passed down to offspring, and will determine whether an offspring will get a particular disease

Which of the following are epigenetic mechanisms? (that is, mechanisms by which gene expression is influenced without any changes to the underlying sequence of DNA)

(choose all that apply)

Question options:

	functional non-coding RNA
	mutations
	DNA methylation
	histone modifications
	Chromatin structure

Answer 1

EPIGENETIC TRANSGENERATIONAL INHERITANCE OF DISEASE SUSCEPTIBILITY MEAN:

OPTION (a)

EPIGENETIC = Changes to factors that affect gene expression

TRANSGENERATIONAL INHERITANCE = That are passed down to offspring

DISEASE SUSCEPTIBILITY = Affect whether or not offfspring will get a particular disease

EPIGENETIC MECHANISMS:

DNA METHYLATION

HISTONE MODIFICATIONS

NON-CODING RNAs

CHROMATIN STRUCTURE