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Discuss the relevance of Ub-dependent degradation for antigen presentation. How could you use a recombinant virus...

Discuss the relevance of Ub-dependent degradation for antigen presentation. How could you use a recombinant virus in order to induce an autoimmune disease?

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Ans. Ub dependent degradation playa a major role in MHC class-I restricted processing of ER targeted proteins and a restricted role in the processing of cytosolic proteins. It was determined by the lysineless polyubiquination of UB and it's impact on cytosolic proteins and the ER targeted proteins. Recombinant viruses act as a vectors by incorporating gene into a heterologous antigen. They deliver genetic code for the antigen into the cells. Furthermore it is replicated to activate the immune cells for triggering the immune response.

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