Question

Which one of the following statements is false?

a. Many growth factor receptors are tyrosine kinases.

b. SH2 is an example of a protein domain that has high affinity binding for phosphorylated EGFR.

c. Raf initiates a serine/threonine kinase cascade.

d. Raf is activated by the kinase activity of RAS.

Which one of the following statements is true?

a. Retroviruses are a major cause of human cancers.

b. Proto-oncogenes are altered forms of normal genes.

c. Oncogenic activation of receptor tyrosine kinases may occur through specific mutations that lead to constitutive tyrosine activation.

d. Oncogenic activation may not occur via epigenetic mechanisms.

Answer 1

1) A statement is false , many growth factor receptors are tyrosine kinase.

Actually reverse statement is true that receptors of tyrosine kinase binds to different type of growth hormone

2) c option correct as certain mutation happen in Tyrosine kinase receptor that leads to continous switch on even in absence of growth factor that results in switch on the cascade pathways and cells continously keep on dividing and ultimately leads to cancer.

Hope it's clear..thanks