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the lining of the trachea and bronchi in chronic smokers changes from pseudostratified ciliated columnar epithelium...

the lining of the trachea and bronchi in chronic smokers changes from pseudostratified ciliated columnar epithelium to stratified squamous epithelium. why do you think this change occurs, and what are some consequences of this change?
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The lining of the trachea and bronchi in chronic smokers changes from pseudostratified ciliated columnar epithelium to stratified squamous epithelium mainly because of the generation of chronic obstructive pulmonary disease (COPD) due to excessive smoking.

Causes:

  • The main features of COPD are basal and goblet cell hyperplasia, squamous cell metaplasia. Squamous metaplasia is change of bronchial epithelium observed in chronic smokers. Squamous metaplasia is process in which quiescent basal cell reenter the cell cycle and hyperactive in nature, and proliferate more rapidly. In this way airways epithelium begins to show the phenotype of squamous and loss its pseudostratified epithelium integrity.
  • One of the main consequences of chronic smoking is structural and functional deformity of ciliated cell line of the lung airway. that will lead to shortened airway cilia and ultimately causes respiratory difficulty.
  • This change in airway epithelium and ciliated cells mainly due to enhanced autophagy in chronic smokers.

Consequences:

These all leads to the overproduction of mucus, decreased mucociliary clearance( due to change in ciliary cell line to stratified epithelium). The pathogens in the lungs are colonized more in this situation, and if this not diagnosed properly lung cancer can be a possibility.

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