Question

1. secreted by postganglionic sympathetic neurons at Islet alpha cells

2. extracellular binding site for (1.)

3. type of membrane protein defined by the topology of (2.)

4. type of (2.) binding site based on its ultimate function

5. found bound to the intracellular face of UN-liganded (2.)

6. immediate consequence of (2.)’s GEF action on (5.)

7. what (6.) directly activates

8. product of (7.)

9. what (8.) directly binds to

10. what (9.) inhibits with its …RRGAI… peptide sequence

11. a term defining the mode of action of the …RRGAI…

12. protein that is one of many substrates for (10.)

13. directly activates movement of glucagon secretory vesicles towards the membrane in response to 1(2.)’s action

14. activates snare function in response to (12.)’s action

Answer options:: None used more than once

A. 7TM B. adenylate cyclase C. CaMKII D. cAMP E. Doc2B F. GPCR G. Gαs/GDP H. Gαs/GTP

I. L-type Ca++ channel J. norepinephrine K. PKA/c subunit L. pseudosubstrate M. R subunit Ν. β2-adrenergic receptor

Answer 1

1. β2 -adrenergic receptor.

2. adenylate cyclase

3. cAMP

4. CaMKII

5.GPCR

6. Gas/GDP

7. Gas/GTP

8.Doc2B

9. 7TM

10. PKA/c subunit

11. R subunit

12. Norepinephrine

13. Pseudosubstrate

14. L type Ca++ channel