Question

Data List 1. Neural Growth Factor (NGF) is a secreted protein 2. P-STAT has a DNA binding site 3. Erk lives in the cytosol 4. P-Erk lives in the nucleus 5. Ras (which is a completely different protein than Ras-GEF) is a GTPase switch so on with GTP and off with GDP 6. Ras-GDP is located at the plasma membrane 7. TrkA has an amino acid that can have a phosphate group added to it (a phosphorylation site) 8. TrkA have a Kinase active site 9. When SPROUTY is present there is no P-Erk 10. P-BRAF + ATP + MEK -->P-BRAF + ADP + P-MEK 11. P-MEK + ATP + ERK --> P-MEK +ADP +P-Erk 12. STAT binds to SPROUTY promoter 13. NGF + TrkA --> NGF-TrkA 14. Ras-Guanine Exchange Factor (RasGEF) promotes the hydrolysis of GTP 15. A STAT mutant stem cell (it cannot make STAT but can make EVERYTHING else) is given NGF (and extra NGF) (and then some more NGF) and the stem cells NEVER become a neuron 16. Ras-GTP + ATP +bRaf --> P-bRaf + ADP + Ras-GTP 17. P-Erk + ATP + STAT --> P-STAT + ADP + P-Erk 18. STAT has a domain that fits in P-Erk active site 19. Cells with a TrkA that cannot be phosphorylated does not have P-Erk 20. If normal stem cells are grown in a dish and never given NGF they stay stem cells. If these normal stem cells are soaked in media with NGF they become neurons

Answer 1

Answering the first part, for the other two questions, re-post the question and specify exact number of the question to be answered.
1.) ERK lives in cytosol of the cytoplasm.
2.) P- ERK lives in the nucleus of the cell.