Aspartic acid has three pKa values, 2.09, 3.86 and 9.82. a. On the following structure for...
Aspartic acid has three pKa values, 2.09, 3.86 and 9.82.
a. On the following structure for this amino acid circle the protons that can be removed and indicate the corresponding pKa value?
b. Determine the value of the isoelectric point for this amino acid.
c. Sketch the structure of the zwitterion.
d. If electrophoresis is carried out at pH is 7.0, will this amino acid migrate to the anode(+) or cathode(-).
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Aspartic acid has three pKa values, 2.09, 3.86 and 9.82.
a. On the following structure for...
5. D-sorbital is found in 'sugar-free' chewing gum. It is formed by reducing D-glucose with NaBH Draw the structure of D-sorbital. s. (4 pts) Classify the following amino acid as polar, n...
5. D-sorbital is found in 'sugar-free' chewing gum. It is formed by reducing D-glucose with NaBH Draw the structure of D-sorbital. s. (4 pts) Classify the following amino acid as polar, non- polar, acidic, or basic: 6 (4 pts) The amino acid threonine (thr) has two chiral carbons. Draw a Fischer projection of the 2S,3S configuration of threonine. キ 7.(11 pts) Draw the tripeptide lys-asp-ser at physiological pH 8. (8 pts) The pK, values for aspartic acid are 2.10, 9.82...
Consider a 0.203 L solution of the amino acid aspartic acid (0.615 M), which has an...
Consider a 0.203 L solution of the amino acid aspartic acid (0.615 M), which has an alpha carboxylic acid group (pka = 2.10), an alpha amine group (pka = 9.82), and a carboxylic acid group in the side chain (pka = 3.86). If the titration is started at a very low pH, how many liters of 2.15 M NaOH would you need to add to reach the isoelectric point of the amino acid? Give your answer to 3 significant figures...
help with this question Consider a 0.211 L solution of the amino acid aspartic acid (0.631...
help with this question
Consider a 0.211 L solution of the amino acid aspartic acid (0.631 M), which has an alpha carboxylic acid group (pka = 2.10), an alpha amine group (pka = 9.82), and a carboxylic acid group in the side chain (pka = 3.86). If the titration is started at a very low pH, how many liters of 2.25 M NaOH would you need to add to reach the isoelectric point of the amino acid? Give your answer...
1. (a) Draw the structure of L-glutamic acid and show its one letter and three letter...
1. (a) Draw the structure of L-glutamic acid and show its one letter and three letter code. (1 pt) (b) Show the calculation for its isoelectric point. (HINT: Check the pKa of the R group also.) (2 pt) (c) Draw the forms of glutamic acid at pH 1, 6 and 10. (3 pt) (d) To which electrode would glutamic acid migrate in electrophoresis at pH 7 buffer, the anode (+) or cathode (-)? (1 pt) (e) MSG (monosodium glutamate) is...
Lysine has pKa values as illustrated on the diagram below a) H3N ОН рК, 2.18 NH3 pKa 10.53 + рка, 8.95 Calculate the is...
Lysine has pKa values as illustrated on the diagram below a) H3N ОН рК, 2.18 NH3 pKa 10.53 + рка, 8.95 Calculate the isoelectric point for lysine i) Draw the predominant structure of lysine at pH>12 i b) The amino acid Tyrosine can be used in automated peptide synthesisers but this requires protected forms of the amino acid H2N ОН Он Tyrosine Show how you can synthesise N-protected and C-protected serine derivatives i) ii Show schematically a method to couple...
2. (10 points) The structure for the amino acid histidine is shown below (at pH 1)....
2. (10 points) The structure for the amino acid histidine is shown below (at pH 1). Write the chemical equations for the ionic dissociations of histidine (as the pH increases) Determine the isoelectric point for histidine and indicate the structure present at the isoelectric point. The pka values for histidine are 1.82 (-CO2H). 9.17 (NH3'), and 6.00 (R group). OOH "HaN NH "INP
What is the pI value for aspartic acid, which has pKa values of 2.1, 3.9, and...
What is the pI value for aspartic acid, which has pKa values of 2.1, 3.9, and 9.8? The answer is (2.1+3.9)/2 = 3.0 What happen to 9.8?? Why this number is not included?
[e] The following shows the chemical structure of aspartic acid and the Ka values for its...
[e] The following shows the chemical structure of aspartic acid and the Ka values for its respective bolded protons (Ka = 1.02 x 10-2) NH CHCH,COOH (Ka = 1.26 x 10-4) COOH (Ka 9.95 x 10-11) ) 12 marks] Give the structure of the most predominant species and the second predominant species at pH3.5. Most predominant species Second predominant species (ii) 12 mark] Give the structure of the most predominant species and the second predominant species at pH 5.5 Most...
m ical reactions 8) Which of the following represents an amino acid in a basic solution...
m ical reactions 8) Which of the following represents an amino acid in a basic solution (pH-11)? A) R-CH-COOR -CH-COOH ENH2 R--CH-COOH R-CH-coo C) NH3 D) 3NH3 9) Which of the following is a zwitterion? B) NH2 R-CH-Coo E) NH2 A) R-CH-COO R-ch-cool R-ca-cooH R-ch-coo H2B) NH2C) NH3 D) NH3 R-ca-coo E) NH2 10) Which of the following amino acids has the lowest isoelectric point? A) glutamic acid B) lysine C) valine D) glycine E) methionine 11) Calculate the isoelectric...
TABLE 5.1 PK values for amino acids 2.36 Amino acid Alanine Arginine Asparagine Aspartic acid Cysteine...
TABLE 5.1 PK values for amino acids 2.36 Amino acid Alanine Arginine Asparagine Aspartic acid Cysteine Glutamic acid Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine PK, PK₂ 2.34 9.69 2.17 9.04 2.02 8.80 1.88 9.60 1.96 10.28 2.19 9.67 2.17 9.13 2.34 9.60 1.82 9.17 9.60 9.60 2.18 8.95 2.28 1.83 9.13 1.99 10.60 2.219.15 2.09 9.10 2.83 9.39 2.20 9.11 2.32 9.62 2.36 9.21 5.56. Of the amino acids listed in Table...
5. D-sorbital is found in 'sugar-free' chewing gum. It is formed by reducing D-glucose with NaBH Draw the structure of D-sorbital. s. (4 pts) Classify the following amino acid as polar, non- polar, acidic, or basic: 6 (4 pts) The amino acid threonine (thr) has two chiral carbons. Draw a Fischer projection of the 2S,3S configuration of threonine. キ 7.(11 pts) Draw the tripeptide lys-asp-ser at physiological pH 8. (8 pts) The pK, values for aspartic acid are 2.10, 9.82...
Consider a 0.203 L solution of the amino acid aspartic acid (0.615 M), which has an alpha carboxylic acid group (pka = 2.10), an alpha amine group (pka = 9.82), and a carboxylic acid group in the side chain (pka = 3.86). If the titration is started at a very low pH, how many liters of 2.15 M NaOH would you need to add to reach the isoelectric point of the amino acid? Give your answer to 3 significant figures...
help with this question
Consider a 0.211 L solution of the amino acid aspartic acid (0.631 M), which has an alpha carboxylic acid group (pka = 2.10), an alpha amine group (pka = 9.82), and a carboxylic acid group in the side chain (pka = 3.86). If the titration is started at a very low pH, how many liters of 2.25 M NaOH would you need to add to reach the isoelectric point of the amino acid? Give your answer...
Lysine has pKa values as illustrated on the diagram below a) H3N ОН рК, 2.18 NH3 pKa 10.53 + рка, 8.95 Calculate the isoelectric point for lysine i) Draw the predominant structure of lysine at pH>12 i b) The amino acid Tyrosine can be used in automated peptide synthesisers but this requires protected forms of the amino acid H2N ОН Он Tyrosine Show how you can synthesise N-protected and C-protected serine derivatives i) ii Show schematically a method to couple...
2. (10 points) The structure for the amino acid histidine is shown below (at pH 1). Write the chemical equations for the ionic dissociations of histidine (as the pH increases) Determine the isoelectric point for histidine and indicate the structure present at the isoelectric point. The pka values for histidine are 1.82 (-CO2H). 9.17 (NH3'), and 6.00 (R group). OOH "HaN NH "INP
[e] The following shows the chemical structure of aspartic acid and the Ka values for its respective bolded protons (Ka = 1.02 x 10-2) NH CHCH,COOH (Ka = 1.26 x 10-4) COOH (Ka 9.95 x 10-11) ) 12 marks] Give the structure of the most predominant species and the second predominant species at pH3.5. Most predominant species Second predominant species (ii) 12 mark] Give the structure of the most predominant species and the second predominant species at pH 5.5 Most...
m ical reactions 8) Which of the following represents an amino acid in a basic solution (pH-11)? A) R-CH-COOR -CH-COOH ENH2 R--CH-COOH R-CH-coo C) NH3 D) 3NH3 9) Which of the following is a zwitterion? B) NH2 R-CH-Coo E) NH2 A) R-CH-COO R-ch-cool R-ca-cooH R-ch-coo H2B) NH2C) NH3 D) NH3 R-ca-coo E) NH2 10) Which of the following amino acids has the lowest isoelectric point? A) glutamic acid B) lysine C) valine D) glycine E) methionine 11) Calculate the isoelectric...
TABLE 5.1 PK values for amino acids 2.36 Amino acid Alanine Arginine Asparagine Aspartic acid Cysteine Glutamic acid Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine PK, PK₂ 2.34 9.69 2.17 9.04 2.02 8.80 1.88 9.60 1.96 10.28 2.19 9.67 2.17 9.13 2.34 9.60 1.82 9.17 9.60 9.60 2.18 8.95 2.28 1.83 9.13 1.99 10.60 2.219.15 2.09 9.10 2.83 9.39 2.20 9.11 2.32 9.62 2.36 9.21 5.56. Of the amino acids listed in Table...
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