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Describe what happens in glutamate metabolism. How does this amino acid work into central metabolism for...

Describe what happens in glutamate metabolism. How does this amino acid work into central metabolism for carbon and energy?

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Glutamate plays an important role in the metabolism of amino acids. It serves to remove the toxic amino (NH2) group from the body. Glutamate is produced in the body as a result of transamination of amino acids, and hydrolysis of glutamine. The glutamate work into central metabolism for carbon and energy by,

  • Oxidative deamination to alpha ketoglutarate
  • Amination to glutamine
  • Decarboxylation to form gamma amino butyric acid (GABA)
  • Formation of N-acetyl glutamate
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