What, ultimately, killed the people that ingested the cyanide? Why did their autopsy indicate that they...
- What, ultimately, killed the people that ingested the cyanide? Why did their autopsy indicate that they died of suffocation, even though they had above-normal levels of oxygen in their blood?
Homework Answers
Answer: Electron transport chain is non-functional
Explanation:
Aerobic respiration involves four major steps
i. Glycolysis
ii. transition reaction
iii. TCA cycle
iv. Electron transport chain
The first three stages produce ATP, NADH, and FADH2.
NADH and FADH2 enter the electron transport chain to produce ATP by
oxidative phosphorylation.
Molecular oxygen is the terminal electron acceptor in aerobic
respiration.
If Cytochrome oxidase is inhibited, electrons cannot be donated
to molecular oxygen (Any defect in the electron carriers would
result in the same phenotype)
This results in the reduced oxidation of NADH and FADH2 to NAD+ and
FAD.
ATP cannot be produced by oxidative phosphorylation
There is no problem with the conversion of glucose to
pyruvate.
This shows that NADH is not getting oxidized to NAD+ i.e. the
electron transport chain is not functional.
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