Question

Pseudomonas aeruginosa is a clinically significant opportunistic pathogen and the main cause of morbidity and mortality associated cystic fibrosis. Briefly describe the disease cystic fibrosis, and detail two (2) specific examples of membrane transport pathway used by P.aeruginosa and their contribution to pathogenesis. [10marks]

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Answer 1

Cystic fibrosis is an autosomal recessive disorder. The disease affects lungs, pancreas, kidneys, intestines and liver. The disease occurs due to mutation in the cystic fibrosis transmembrane conductance (CFTR) gene.

Pseudomonas aureginosa is a bacteria that infects cystic fibrosis patients after the mucoid secretions clog and instruct their airways in lungs. The bacteria attaches to TLR4 and PIP2 receptors and alters membrane transport pathway in the respiratory pathways.