The measured osmolarity of the 47-year-old man in our case is given to be 321 mOsM...
The measured osmolarity of the 47-year-old man in our case is given to be 321 mOsM
(Table 1). The osmol gap is the difference between the measured and calculated osmolality.
Answer the following questions regarding osmol gap.
a. The osmol gap was considered to be in the normal range, despite the other
clinical evidence of ethylene glycol intoxication. Explain why the osmol gap was
not sufficiently elevated to be clinically useful for the diagnosis. Consider the
time course of the case and the potential artifacts in your answer. (3 points)
b.
If the man had ingested ethanol in addition to ethylene glycol, how would you
account for that in calculating the osmol gap? Would you predict a change in the
time course of the osmol gap and anion gap for ethanol versus ethylene glycol
ingestion? Why or why not?
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