A pytochemical known as Barago has been found to be a competitive inhibitor of 2,3- Biphosphoglycerate...
A pytochemical known as Barago has been found to be a competitive inhibitor of 2,3- Biphosphoglycerate on hemoglobin. What would be the effect of Barago on: (i) Adult hemoglobin and (ii) fetal hemoglobin binding of oxygen and carbon dioxide? Please answer in at least 5 sentences. No info is needed on Barago except that it is a competitive inhibitor 2,3- Biphosphoglycerate on hemoglobin.
Homework Answers
(i) 2,3-bisphosphoglycerate (2,3-BPG) decreases oxygen affinity of adult hemoglobin, stabilising its taut conformation. Since Barago is a competitive inhibitor of 2,3-BPG, it would destabilise the T state resulting in increased oxygen affinity. Consequently, this would result in inefficient oxygen delivery to the peripheral tissues and impaired removal of carbon dioxide.
(ii) Fetal hemoglobin only weakly binds 2,3-BPG, resulting in its higher oxygen affinity compared to adult hemoglobin. So Barago, as a competitive inhibitor of 2,3-BPG, would further increase the oxygen affinity of fetal hemoglobin.
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