Question

13. [8 pts) Supply the missing word (s) in each of the following questions. Choose from increase, decrease, or remain unchanged. Increasing the concentration of 2, 3 BPG causes the affinity for oxygen in fetal hemoglobin to Decreasing the pH of a solution of hemoglobin causes the affinity for carbon dioxide to Increasing the concentration of 2,3 BPG causes the affinity for oxygen in adult hemoglobin to Increase the pCO2 from 10 to 40 torts causes the affinity for oxygen to Increasing the number of negatively charged amino acids in the central cavity will cause the affinity for 2, 3 BPG to Decreasing the concentration of carbon dioxide in a solution of hemoglobin causes the affinity of His HC3 to bind with Arg FGI Decreasing the affinity of proximal His for Fe causes the affinity of oxygen to Decreasing the affinity of hemoglobin for 2.3 BPG causes the affinity of oxygen to Increasing the concentration of CO in a solution of hemoglobin causes the afinity for oxygen to Increasing the concentration of H+ in a solution of hemoglobin causes the affinity for carbon dioxide to Decreasing the affinity of His 64 for HisHC3 causes the affinity for Oto As the pH of a solution of hemoglobin increases the affinity for oxygen As the pH of solution of hemoglobin decreases the affinity for oxyzen Increasing the partial pressure of oxygen for a solution of hemoglobin causes the affinity for O to Decreasing the affinity of hemoglobin for 2.3 RPG causes the affinity of H+ to Increasing the OH concentration of a solution of hemoglobin causes the affinity for Oxygen
please answer all.

Answer 1

This Picture will clear most of the concepts-

Left shift Decreased temp Decreased 2-3 DPG Decreased [H+] CO Oxyhemoglobim (%Saturation) Right shift (reduced affinity) Increased temp Increased 2-3 DPG Increased (H+) 0 10 20 30 80 90 100 40 50 60 70 Po, (mmHg)

1. Remain Unchanged (In Fetal No beta chain)

2. Increases the affinity to bind haemoglobin and Carbon Di-Oxide.

3. Decreases the affinity of Hb and Oxygen.

4. Decreases the affinity of Hb and Oxygen.

5. Decreases the affinity of BPG binding with oxygen.

6. Decreases Because lower the CO2 and Higher the pH and lower the H+ ions (Higher pH causes His HC3 side chain to deprotonate and lose its charge This breaks the ion pair with Asp FG1)

7. Decrease of oxygen affinity

8. Increase in the affinity of Oxygen Binding.

9. Decreases the oxygen affinity (Smoking is best example)

10. Increases the affinity to bind haemoglobin and Carbon Di-Oxide.

11. to decrease.

12. pH increases and H+ decreases and oxygen affinity increases.

13. pH decrease and H+ increase and oxygen affinity decreases.

14. Hemoglobin is preferred as there are a higher pO2 and more oxygen bound.

15. Decreases (because pH will increase).

16. Affinity for oxygen affinity will Increase. (because pH is proposaly to OH- )

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